Protein Information

Name Stress Activated Protein Kinase
Synonyms Mitogen activated protein kinase 8; JNK 1; JNK 46; JNK1; JNK1 alpha protein kinase; JNK1 beta protein kinase; JNK1A2; JNK21B1/2…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
17996917 Refsnes M, Skuland T, Schwarze PE, Ovrevik J, Lag M: Fluoride-induced IL-8 release in human epithelial lung cells: relationship to EGF-receptor-, SRC- and MAP-kinase activation. Toxicol Appl Pharmacol. 2008 Feb 15;227(1):56-67. Epub 2007 Oct 3.

Sodium fluoride strongly activated MAPK, in particular JNK1/2 and p38.
85(1,1,1,5) Details
11346645 Aoyama K, Nagata M, Oshima K, Matsuda T, Aoki N: Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain. J Biol Chem. 2001 Jul 20;276(29):27575-83. Epub 2001 May 9.


Recombinant LMW-DSP2 protein exhibited phosphatase activity toward an artificial low molecular weight substrate para-nitrophenyl phosphate, and the activity was inhibited completely by sodium orthovanadate but not sodium fluoride, pyrophosphate, and okadaic acid.
0(0,0,0,0) Details