Protein Information

Name gamma glutamyltransferase
Synonyms CD224; CD224 antigen; D22S672; D22S732; GGT; GGT 1; GGT1; GGT1 protein…

Compound Information

Name 1,2-dichloropropane
CAS 1,2-dichloropropane

Reference List

PubMed Abstract RScore(About this table)
8096708 Trevisan A, Meneghetti P, Maso S, Troso O: In-vitro mechanisms of 1,2-dichloropropane nephrotoxicity using the renal cortical slice model. Hum Exp Toxicol. 1993 Mar;12(2):117-21.

Acivicin and aminooxyacetic acid, inhibitors of gamma-glutamyltransferase and beta-lyase activity, respectively, partially but significantly prevent the loss of organic anion accumulation induced by 1,2-dichloropropane.
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1482287 Trevisan A, Meneghetti P, Maso S, Secondin L, Nicoletto G: Sex- and age-related nephrotoxicity due to 1,2-dichloropropane in vitro. Arch Toxicol. 1992;66(9):641-5.

Reduced glutathione content, organic anion accumulation (p-aminohippurate), and release of malondialdehyde (to measure the extent of lipid peroxidation), aspartate aminotransferase, gamma-glutamyltransferase and lactate dehydrogenase into the incubation medium were determined.
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1980407 Imberti R, Mapelli A, Colombo P, Richelmi P, Berte F, Bellomo G: 1,2-Dichloropropane (DCP) toxicity is correlated with DCP-induced glutathione (GSH) depletion and is modulated by factors affecting intracellular GSH. Arch Toxicol. 1990;64(6):459-65.

Acute 1,2-dichloropropane (DCP) poisoning in humans is relatively frequent in Italy, where DCP is widely diffused as a constituent of commercial solvents and dry cleaners.
GSH depletion was associated with a marked increase in serum GOT, GPT, 5'-nucleotidase, gamma-glutamyl transpeptidase, alkaline phosphatase, urea and creatinine, and a significant degree of hemolysis.
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