| Name | GSTM1 |
|---|---|
| Synonyms | GST class mu 1; Glutathione S alkyltransferase; MU; GST1; GSTM 1; GSTM1; GSTM1 protein; GSTM1 1… |
| Name | ethylene oxide |
|---|---|
| CAS | oxirane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16918316 | Bolt HM, Thier R: Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology. Curr Drug Metab. 2006 Aug;7(6):613-28. |
4(0,0,0,4) | Details |
| 12872524 | Thier R, Bruning T, Roos PH, Rihs HP, Golka K, Ko Y, Bolt HM: Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes. Int J Hyg Environ Health. 2003 Jun;206(3):149-71. The human polymorphic GST catalysing conjugation of halomethanes, dihalomethanes, ethylene oxide and a number of other industrial compounds could be characterised as a class theta enzyme (GSTT1) by means of molecular biology. "Conjugator" and "non-conjugator" phenotypes are coincident with the presence and absence of the GSTT1 gene. Again, in most cases, the effect of the variant CYP1A1 allele becomes apparent or clearer in connection with the GSTM1 null allele. |
3(0,0,0,3) | Details |
| 17416773 | Haufroid V, Merz B, Hofmann A, Tschopp A, Lison D, Hotz P: Exposure to ethylene oxide in hospitals: biological monitoring and influence of glutathione S-transferase and epoxide hydrolase polymorphisms. Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):796-802. GSTs (GSTT1, GSTM1, and GSTP1) and epoxide hydrolase (EPHX1) were also genotyped. |
1(0,0,0,1) | Details |
| 15668107 | Paulsson B, Rannug A, Henderson AP, Golding BT, Tornqvist M, Warholm M: In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood. Mutat Res. 2005 Feb 7;580(1-2):53-9. Blood samples from individuals with different genotypes for GSTT1 and GSTM1 were studied. In a parallel experiment, incubation with ethylene oxide was used as positive control. |
1(0,0,0,1) | Details |
| 16386346 | Godderis L, Aka P, Mateuca R, Kirsch-Volders M, Lison D, Veulemans H: Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene oxide, ethylene oxide and gamma-radiation. Toxicology. 2006 Feb 15;219(1-3):220-9. Epub 2005 Dec 28. In this study we assessed the dose-dependent effect of genetic polymorphisms in biotransforming (EPHX (Tyr113/His113 and His139/Arg139), GSTP1 (Ile105/Val105), GSTM1 and GSTT1) and DNA repair enzymes (hOGG1 (Ser326/Cys326), XRCC1 (Arg194/Trp194, Arg280/His280, Arg399/Gln399), XRCC3 (Thr241/Met241)) on the induced genotoxicity. |
1(0,0,0,1) | Details |
| 15055296 | Norppa H: Cytogenetic biomarkers. IARC Sci Publ. 2004;(157):179-205. These findings may be explained by reduced detoxification capacity rendered by the altered gene and may be linked with exposure to, for example, heterocyclic amines in the case of NAT2 and endogenously formed ethylene oxide in the case of GSTT1. The lack of glutathione S-transferase M1 (GSTM1 null genotype) appears to be associated with increased sensitivity to genotoxicity of tobacco smoking. |
1(0,0,0,1) | Details |