| Name | CYP3A |
|---|---|
| Synonyms | CP33; CYP3; HLP; CYP3A; CP34; CYP 3A4; CYP 3; CYP3A3… |
| Name | methylene chloride |
|---|---|
| CAS | dichloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8971132 | Edwards DJ, Bellevue FH 3rd, Woster PM: Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice. Drug Metab Dispos. 1996 Dec;24(12):1287-90. Grapefruit juice was extracted into methylene chloride and chromatographed by HPLC, and the effect of the HPLC eluent on CYP3A activity was assessed by measuring 6beta-hydroxytestosterone formation in rat liver microsomes. |
8(0,0,1,3) | Details |
| 16719384 | Waxman DJ, Chang TK: Thin-layer chromatography analysis of human CYP3A-catalyzed 6beta-hydroxylation. Methods Mol Biol. 2006;320:133-41. |
4(0,0,0,4) | Details |
| 17620348 | Kim SN, Seo JY, Jung da W, Lee MY, Jung YS, Kim YC: Induction of hepatic CYP2E1 by a subtoxic dose of in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation. Drug Metab Dispos. 2007 Oct;35(10):1754-8. Epub 2007 Jul 9. Western blot analysis showed that treatment induced the expression of CYP2E1 and CYP3A proteins. |
2(0,0,0,2) | Details |
| 18520608 | Dennison JB, Renbarger JL, Walterhouse DO, Jones DR, Hall SD: Quantification of vincristine and its major metabolite in human plasma by high-performance liquid chromatography/tandem mass spectrometry. Ther Drug Monit. 2008 Jun;30(3):357-64. An analytical method using electrospray ionization and high-performance liquid chromatography/tandem mass spectrometry (LC/ESI-MS/MS) was developed to quantify vincristine and M1, the CYP3A-mediated metabolite of vincristine, in human plasma. Vinblastine (internal standard), vincristine, and M1 in plasma were extracted in methylene chloride after acidification with TCAA. |
1(0,0,0,1) | Details |
| 10872584 | Madani S, Howald WN, Lawrence RF, Shen DD: Analysis of hydroxylated and N-dealkylated metabolites of terfenadine in microsomal incubates by liquid chromatography--mass spectrometry. J Chromatogr B Biomed Sci Appl. 2000 May 12;741(2):145-53. The reproducibility and sensitivity of the assay, combined with the selectivity of mass spectrometric detection, should allow an accurate kinetic characterization of terfenadine oxidation mediated by the high affinity CYP3A enzymes in human liver and intestinal microsomes. Terfenadine metabolites were extracted from basified microsomal incubates into methylene chloride. |
1(0,0,0,1) | Details |
| 10574192 | Testino SA Jr, Ozarowski J, Thurston AW, Arrendale RF, Patonay G: Determination of and 6beta-hydroxytestosterone by gas chromatography-selected ion monitoring-mass spectrometry for the characterization of cytochrome p450 3A activity. J Chromatogr B Biomed Sci Appl. 1999 Oct 29;734(1):73-81. The assay has been used to characterize the CYP3A metabolic activity of multiple preparations of human, rat, and dog liver microsomes. and its metabolites are extracted from the incubation mixture in a single step with methylene chloride. |
1(0,0,0,1) | Details |