| Name | CYP2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | naphthalene |
|---|---|
| CAS | naphthalene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16959878 | Chang JH, Kochansky CJ, Shou M: The role of P-glycoprotein in the bioactivation of raloxifene. . Drug Metab Dispos. 2006 Dec;34(12):2073-8. Epub 2006 Sep 7. In the presence of the CYP2E inhibitor 4-methylpyrazole, a decrease in naphthalene covalent binding was observed, suggesting that the formation of the 1,2-epoxide may be the main culprit contributing to naphthalene covalent binding. |
31(0,1,1,1) | Details |
| 19116287 | Li Z, Okano S, Yoshinari K, Miyamoto T, Yamazoe Y, Shinya K, Ioku K, Kasai N: Soft-hydrothermal processing of red cedar bedding reduces its induction of cytochrome P450 in mouse liver. Lab Anim. 2009 Apr;43(2):205-11. Epub 2008 Dec 30. Between days 1 and 2 after administration, hepatic P450s were significantly induced as follows: CYP3As, 7.1x; CYP1As, 1.6x; CYP2E1, 1.5x; CYP2Cs, 1.6x. In particular, several volatile sesquiterpenes, naphthalene-derived aromatics and 4,4-dimethyl-13alpha-androst-5-ene were decreased in the ST-cedar bedding, suggesting that these may be responsible for P450 induction. |
2(0,0,0,2) | Details |
| 19589367 | Cruzan G, Bus J, Banton M, Gingell R, Carlson G: Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action. Regul Toxicol Pharmacol. 2009 Nov;55(2):205-18. Epub 2009 Jul 7. The absence of a role for CYP2E1-generated metabolites (primarily alkyl oxidation vs. ring-oxidation) in mouse pulmonary effects was demonstrated by the lack of protection from styrene toxicity by CYP2E1 inhibitor, or reduction of toxicity in CYP2E1-knockout mice, and lack of lung toxicity of the primary metabolite of ethylbenzene. For naphthalene, and styrene, inhibition of toxicity with inhibition of CYP2F2 has been demonstrated. |
1(0,0,0,1) | Details |