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Talavera K, Gees M, Karashima Y, Meseguer VM, Vanoirbeek JA, Damann N, Everaerts W, Benoit M, Janssens A, Vennekens R, Viana F, Nemery B, Nilius B, Voets T: Nicotine activates the chemosensory cation channel TRPA1. . Nat Neurosci. 2009 Oct;12(10):1293-9. Epub 2009 Sep 13.
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Xiao R, Xu XZ: Function and regulation of TRP family channels in C. elegans. Pflugers Arch. 2009 Sep;458(5):851-60. Epub 2009 May 8.
For example, the TRPC channels TRP-1 and TRP-2 control nicotine-dependent behavior, while TRP-3, a sperm TRPC channel, is regulated by sperm activation and required for sperm-egg interactions during fertilization. For instance, the TRPV channels OSM-9 and OCR-2 act in chemosensation, osmosensation, and touch sensation, the TRPA member TRPA-1 regulates touch sensation, while the TRPN channel TRP-4 mediates proprioception. |
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