Protein Information

Name nucleolin
Synonyms C23; NCL; Nucleolin; Protein C23; Nucleolins; Protein C23s

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
19409963 Caudle WM, Kitsou E, Li J, Bradner J, Zhang J: A role for a novel protein, nucleolin, in Parkinson's disease. Neurosci Lett. 2009 Jul 31;459(1):11-5. Epub 2009 May 4.

Furthermore, manipulation of nucleolin in an in vitro model of PD resulted in significant alterations in the generation of oxidative stress as well as proteasomal inhibition following rotenone exposure.
34(0,1,1,4) Details
16854843 Jin J, Li GJ, Davis J, Zhu D, Wang Y, Pan C, Zhang J: Identification of novel proteins associated with both alpha-synuclein and DJ-1. Mol Cell Proteomics. 2007 May;6(5):845-59. Epub 2006 Jul 18.

In the current study, we analyzed proteins associated with alpha-synuclein and/or DJ-1 with a robust proteomics technique called stable isotope labeling by amino acids in cell culture (SILAC) in dopaminergic MES cells exposed to rotenone versus controls.
A subset of these proteins (mortalin, nucleolin, grp94, calnexin, and clathrin) was further validated for their association with both alpha-synuclein and DJ-1 using confocal microscopy, Western blot, and/or immunoprecipitation.
1(0,0,0,1) Details