| Name | P2X receptor (protein family or complex) |
|---|---|
| Synonyms | P2X receptor; P2X receptors |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15331767 | Mason HS, Bourke S, Kemp PJ: Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive species. Mol Pharmacol. 2004 Dec;66(6):1525-35. Epub 2004 Aug 26. Inhibitors of the mitochondrial electron transport chain that reduce (rotenone and myxothiazol) or increase (antimycin A) the production of ROS altered the magnitude of P2X2-mediated currents. Purinergic excitatory synapses use ATP to mediate fast synaptic transmission via activation of P2X receptor cation channels, and this response can be altered by acute hypoxia. |
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| 19793987 | Coddou C, Codocedo JF, Li S, Lillo JG, Acuna-Castillo C, Bull P, Stojilkovic SS, Huidobro-Toro JP: Reactive species potentiate the P2X2 receptor activity through intracellular Cys430. J Neurosci. 2009 Sep 30;29(39):12284-91. P2X receptor channels (P2XRs) are allosterically modulated by several compounds, mainly acting at the ectodomain of the receptor. Because mercury could act as an oxidative stress inducer, we also tested whether peroxide (H (2) O (2)) and mitochondrial stress inducers myxothiazol and rotenone mimicked mercury effects. |
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