| Name | CIP1 |
|---|---|
| Synonyms | CAP20; CDKN1A; Cip1; PIC 1; PIC1; P21; CDK interacting protein 1; CDK interaction protein 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15729575 | Artwohl M, Furnsinn C, Waldhausl W, Holzenbein T, Rainer G, Freudenthaler A, Roden M, Baumgartner-Parzer SM: Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. Diabetologia. 2005 Mar;48(3):586-94. Epub 2005 Feb 24. Whereas p21WAF-1/Cip1 and p27Kip were differently affected in HUVECs, all agents reduced (p <0.05) expression of cyclins (D3, A, E, B), cyclin-dependent kinase-2 and hyperphosphorylated retinoblastoma protein. Proliferation inhibition and lactate release were mimicked by rotenone (mitochondrial complex I inhibitor). |
1(0,0,0,1) | Details |
| 9661904 | Heerdt BG, Houston MA, Anthony GM, Augenlicht LH: Mitochondrial membrane potential (delta psi (mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells. Cancer Res. 1998 Jul 1;58(13):2869-75. Here, we dissect the relationships among mitochondrial function, growth arrest, and apoptosis, reporting that initiation and maintenance of -mediated p53-independent p21WAF1/Cip1 induction and subsequent G0/G1 arrest require an intact mitochondrial membrane potential (delta psi (mt)) and that the process of dissipation of the delta psi (mt) is then essential for initiation of a -induced apoptotic cascade. |
1(0,0,0,1) | Details |
| 19091749 | Liu Y, Veena CK, Morgan JB, Mohammed KA, Jekabsons MB, Nagle DG, Zhou YD: Methylalpinumisoflavone inhibits hypoxia-inducible factor-1 (HIF-1) activation by simultaneously targeting multiple pathways. J Biol Chem. 2009 Feb 27;284(9):5859-68. Epub 2008 Dec 17. At the concentrations that in hibited HIF-1 activation, compound 2 inhibited hypoxic induction of HIF-1 target genes (CDKN1A, GLUT-1, and VEGF), tumor angiogenesis in vitro, cell migration, and chemotaxis. Mechanistic studies indicate that, unlike rotenone and other mitochondrial inhibitors, compound 2 represents the first small molecule that inhibits HIF-1 activation by simultaneously suppressing mitochondrial respiration and disrupting protein translation in vitro. |
1(0,0,0,1) | Details |
| 10951577 | Chandel NS, Vander Heiden MG, Thompson CB, Schumacker PT: Redox regulation of p53 during hypoxia. . Oncogene. 2000 Aug 10;19(34):3840-8. The p53-dependent gene p21WAF1/CIP1 was also induced by hypoxia in both MCF-7 and IMR-90 cells without affecting the growth rate of either cell line. Rotenone, an inhibitor of mitochondrial complex I, and 4,4'-diisothiocyanato-stilbene-2,2'-disulfonate, a mitochondrial anion channel inhibitor, also abolished the increase in ROS signal and p53 levels during hypoxia. |
2(0,0,0,2) | Details |