| Name | cytochrome bc1 |
|---|---|
| Synonyms | Cytochrome bc1; D3S3191; UQCRC 1; UQCRC1; Ubiquinol cytochrome C reductase complex core protein I mitochondrial; Ubiquinol cytochrome c reductase core protein I; Ubiquinol cytochrome C reductase complex core protein I mitochondrials; Ubiquinol cytochrome c reductase core protein Is |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6321855 | Kelley RI, Corkey BE: Increased sensitivity of cerebrohepatorenal syndrome fibroblasts to antimycin A. J Inherit Metab Dis. 1983;6(4):158-62. Compared to normal fibroblasts, CHRS cells demonstrated a fivefold greater sensitivity to antimycin A, an inhibitor of the cytochrome bc1 complex (complex III), but equal inhibition by amytal, rotenone and 2-heptyl-4-hydroxyquinoline-N-oxide. |
81(1,1,1,1) | Details |
| 2860103 | Stoner CD: Steady-state kinetics of the overall oxidative phosphorylation reaction in heart mitochondria. J Bioenerg Biomembr. 1985 Apr;17(2):85-108. The results indicate that in accordance with the chemiosmotic theory the intermediate reactants that link the energy-yielding rotenone-sensitive (Site 1), cytochrome bc1 (Site 2), and cytochrome aa3 (Site 3) reactions of the respiratory chain to the energy-consuming ATP synthetase, AdN transport, and Pi transport reactions are freely diffusible (delocalized). |
31(0,1,1,1) | Details |
| 8078526 | Beattie DS, Obungu VH, Kiaira JK: Oxidation of by a rotenone and antimycin-sensitive pathway in the mitochondrion of procyclic Trypanosoma brucei brucei. Mol Biochem Parasitol. 1994 Mar;64(1):87-94. NADH:cytochrome c reductase activity was 75% inhibited by concentrations of antimycin that inhibited 95% succinate:cytochrome c reductase activity suggesting that the major pathway for oxidation in the mitochondria involved the cytochrome bc1 complex of the electron transfer chain. |
1(0,0,0,1) | Details |
| 403946 | Kilpatrick L, Erecinska M: Mitochondrial respiratory chain of Tetrahymena pyriformis. Biochim Biophys Acta. 1977 May 11;460(2):346-63. The respiration is more than 90% inhibited with 1 mM while antimycin A and rotenone inhibit at concentrations of 1000-fold higher than those effective in mammalian mitochondria. In the cytochrome bc1 region of the chain a cytochrome c was present with an Em7.2 of 0.225 V and two components with absorption maxima at 560 nm and the half-reduction potential values of -0.065 and -0.15 V at pH 7.2. |
1(0,0,0,1) | Details |
| 2332054 | Brustovetsky NN, Amerkhanov ZG, Popova EYu, Konstantinov AA: Reversible inhibition of electron transfer in the FEBS Lett. 1990 Apr 9;263(1):73-6. The inhibition site is likely to be localized between and the cytochrome bc1 complex. |
1(0,0,0,1) | Details |
| 12241070 | Mildaziene V, Nauciene Z, Krab K: The targets of 2,2',5,5'-tetrachlorobiphenyl in the respiratory chain of rat liver mitochondria revealed by modular kinetic analysis. Mol Biol Rep. 2002;29(1-2):31-4. The effects of 20 microM 2,2',5,5'-TCB on the activity of the respiratory chain modules in rat liver mitochondria oxidizing (+ rotenone) in state 3 were assessed. |
0(0,0,0,0) | Details |
| 11358527 | Fang J, Wang Y, Beattie DS: Isolation and characterization of complex I, rotenone-sensitive oxidoreductase, from the procyclic forms of Trypanosoma brucei. Eur J Biochem. 2001 May;268(10):3075-82. |
0(0,0,0,0) | Details |
| 16895522 | Sherwood S, Hirst J: Investigation of the mechanism of translocation by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria: does the enzyme operate by a Q-cycle mechanism?. Biochem J. 2006 Dec 15;400(3):541-50. Here, we describe experiments to determine whether complex I, isolated from bovine heart mitochondria, operates via a Q-cycle mechanism analogous to that observed in the cytochrome bc1 complex. Unexpectedly, in the presence of complex I inhibited by either rotenone or piericidin A was found to catalyse the exchange of redox states between different and species, providing a possible route for future investigations into the mechanism of energy transduction. |
1(0,0,0,1) | Details |