Protein Information

Name phenol sulfotransferase
Synonyms Aryl sulfotransferase; STP; Aryl sulfotransferase 1; HAST1/HAST2; P PST; P PST 1; PST; Phenol preferring phenol sulfotransferase 1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
11824526 Mesia-Vela S, Sanchez RI, Estrada-Muniz E, Alavez-Solano D, Torres-Sosa C, Jimenez M, Estrada, Reyes-Chilpa R, Kauffman FC: Natural products isolated from Mexican medicinal plants: novel inhibitors of sulfotransferases, SULT1A1 and SULT2A1. Phytomedicine. 2001 Nov;8(6):481-8.

Rotenone from a commercial source had potency comparable to that of the flavonoids isolated from Lonchocarpus for inhibiting both SULTs.
7(0,0,0,7) Details
2870893 Dills RL, Klaassen CD: The effect of inhibitors of mitochondrial energy production on hepatic glutathione, UDP-glucuronic acid, and adenosine 3'-phosphate-5'-phosphosulfate concentrations. Drug Metab Dispos. 1986 Mar-Apr;14(2):190-6.

This was shown to be a property shared with phenolic inhibitors of phenol sulfotransferase.
This proposal was examined in vivo by quantitating hepatic adenine nucleotides and co-substrates in rats treated with the following inhibitors of mitochondrial ATP production: rotenone, antimycin A, carbonyl cyanide m-chlorophenylhydrazone, and 2,4-dinitrophenol.
1(0,0,0,1) Details