| Name | NF E2 related factor 2 |
|---|---|
| Synonyms | HEBP 1; HEBP1; NF E2 related factor 2; NFE2 related factor 2; NFE2 related trancription factor 2; NFE2L2; NRF 2; NRF2… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19131585 | Han Z, Varadharaj S, Giedt RJ, Zweier JL, Szeto HH, Alevriadou BR: Mitochondria-derived reactive species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther. 2009 Apr;329(1):94-101. Epub 2009 Jan 8. Bovine aortic endothelial cells (ECs) respond to (NO) donors by activating the redox-sensitive NF-E2-related factor 2/antioxidant response element pathway and up-regulating heme oxygenase (HO)-1 expression. The mitochondrial electron transport chain inhibitors, myxothiazol, rotenone, or antimycin A, and the mitochondria-targeted antioxidant peptide, Szeto-Schiller (SS)-31, which scavenges O (2)(*-), peroxide (H (2) O (2)), and markedly inhibited the increase in HO-1 expression. |
1(0,0,0,1) | Details |
| 12842875 | Lee JM, Shih AY, Murphy TH, Johnson JA: NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular in primary cortical neurons. J Biol Chem. 2003 Sep 26;278(39):37948-56. Epub 2003 Jul 3. Nrf2-/- neurons in this mixed culture system were more sensitive to mitochondrial toxin (1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine or rotenone)-induced apoptosis compared with Nrf2+/+ neurons. |
2(0,0,0,2) | Details |
| 18373731 | Minelli A, Conte C, Grottelli S, Bellezza M, Cacciatore I, Bolanos JP: Cyclo (His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence. J Cell Mol Med. 2009 Jun;13(6):1149-61. Epub 2008 Mar 29. Here, we addressed this issue and found that cyclo (His-Pro) triggered nuclear accumulation of NF-E2-related factor-2 (Nrf2), a transcription factor that up-regulates antioxidant-/electrophile-responsive element (ARE-EpRE)-related genes, in PC12 cells. Cyclo (His-Pro) attenuated reactive species production, and prevented depletion caused by rotenone, paraquat and beta-amyloid treatment. |
1(0,0,0,1) | Details |
| 17360324 | Liu Y, Kern JT, Walker JR, Johnson JA, Schultz PG, Luesch H: A genomic screen for activators of the antioxidant response element. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5205-10. Epub 2007 Mar 12. Overexpression of SQSTM1 and DPP3 in IMR-32 cells stimulated NF-E2-related factor 2 (NRF2) nuclear translocation and led to increased levels of NAD (P) H:quinone oxidoreductase 1, a protein which is transcriptionally regulated by the ARE. Overexpression of these cDNAs conferred partial resistance to peroxide or rotenone-induced toxicity, consistent with the induction of antioxidant and phase II detoxification enzymes, which can protect from oxidative stress. |
1(0,0,0,1) | Details |