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Kondo RP, Wang SY, John SA, Weiss JN, Goldhaber JI: Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes. J Mol Cell Cardiol. 2000 Oct;32(10):1859-72.
Using the whole cell patch clamp technique, we found that metabolic inhibitors activated a non-selective current permeant to both small and large cations, and blocked by La (3+), similar to the properties of connexin 43 when overexpressed in human embryonic kidney (HEK) cells. |
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