Protein Information

Name p50
Synonyms ARHGEF 7; PAK3; p85; p50; ARHGEF7; BETA PIX; COOL 1; COOL1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
14713113 Gnaiger E: Oxygen conformance of cellular respiration. Adv Exp Med Biol. 2003;543:39-55.

In cultured cells, the pronounced oxygen uptake above mitochondrial saturation at air-level oxygen pressure cannot be inhibited by rotenone and antimycin A, amounting to > 20 % of routine respiration in fibroblasts.
Respiration of isolated heart mitochondria follows hyperbolic oxygen kinetics with half-saturating oxygen pressure, p50, of 0.04 kPa (0.3 Torr; 0.4 microM) in ADP-stimulated state 3.
2(0,0,0,2) Details
9475164 Wiedemann FR, Kunz WS: Oxygen dependence of flux control of cytochrome c oxidase -- implications for mitochondrial diseases. FEBS Lett. 1998 Jan 23;422(1):33-5.


The result is in line with the high oxygen sensitivity of maximal respiration of saponin-permeabilized muscle fibers (P50 = 33 microM) caused most probably by oxygen diffusion gradients through the fiber lattice.
1(0,0,0,1) Details