| Name | vascular cell adhesion molecule 1 |
|---|---|
| Synonyms | CD106; L1CAM; CD106 antigen; INCAM 100; INCAM100; V CAM 1; VCAM 1; VCAM1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15845907 | Basta G, Lazzerini G, Del Turco S, Ratto GM, Schmidt AM, De Caterina R: At least 2 distinct pathways generating reactive species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products. Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1401-7. Epub 2005 Apr 21. The inhibition of NAD (P) H oxidase by apocynin and diphenylene iodonium, and of the mitochondrial electron transport system at complex II by thenoyltrifluoroacetone (TTFA), significantly inhibited both AGE-induced ROS production and VCAM-1 expression, whereas these effects were potentiated by rotenone and antimycin A, specific inhibitors of mitochondrial complex I and III, respectively. |
36(0,1,1,6) | Details |
| 10712386 | Pueyo ME, Gonzalez W, Nicoletti A, Savoie F, Arnal JF, Michel JB: Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress. Arterioscler Thromb Vasc Biol. 2000 Mar;20(3):645-51. In contrast, rotenone and antimycin, 2 inhibitors of the mitochondrial respiratory chain, inhibited the Ang II-induced IkappaB degradation, showing that generation of reactive species in the mitochondria is involved on Ang II action. |
5(0,0,0,5) | Details |
| 15090367 | Ali MH, Pearlstein DP, Mathieu CE, Schumacker PT: Mitochondrial requirement for endothelial responses to cyclic strain: implications for mechanotransduction. Am J Physiol Lung Cell Mol Physiol. 2004 Sep;287(3):L486-96. Epub 2004 Apr 16. Increases in NF-kappaB activation and VCAM-1 mRNA expression during strain were prevented by antioxidants. Mitochondrial inhibitors diphenylene iodonium or rotenone abrogated this response, whereas inhibitors of (NO) synthase (L-nitroarginine), xanthine oxidase (allopurinol), or NAD (P) H oxidase (apocynin) had no effect. |
2(0,0,0,2) | Details |
| 15749729 | Simoncini S, Sapet C, Camoin-Jau L, Bardin N, Harle JR, Sampol J, Dignat-George F, Anfosso F: Role of reactive species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome. Int Immunol. 2005 Apr;17(4):489-500. Epub 2005 Mar 4. ROS inhibition observed in the presence of diphenylene iodonium and rotenone indicated an involvement of a membrane-bound oxidase and the mitochondrial transport chain as sources of ROS. ROS controlled the up-regulation of vascular cell adhesion molecule-1 expression by IgG-APS-stimulated HUVEC and the increase in THP-1 monocytic cells adhesion. |
1(0,0,0,1) | Details |