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Zhang C, Park Y, Picchi A, Potter BJ: Maturation-induces endothelial dysfunction via vascular inflammation in diabetic mice. Basic Res Cardiol. 2008 Sep;103(5):407-16. Epub 2008 Jul 3.
NAD (P) H oxidase inhibitor apocynin attenuated superoxide production in db/db mice at 12 weeks of age, mitochondria respiratory chain inhibitor rotenone attenuated superoxide production at 24 weeks in db/db and Db/db mice, but the combination of apocynin and rotenone reduced superoxide production at 18 weeks for db/db and Db/db mice.
Plasma concentration, expression of TNFalpha and TNFalpha receptor 1 (TNFR1) were elevated in coronary arterioles, even at the age of 6 weeks before the development of diabetes in db/db mice compared to control mice. |
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