| Name | p42 |
|---|---|
| Synonyms | CDC2 related kinase 1; p42; CDKL 1; CDKL1; Cyclin dependent kinase like 1; KKIALRE; Protein kinase p42 KKIALRE; Serine/threonine protein kinase KKIALRE… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14672949 | Sawada H, Kohno R, Kihara T, Izumi Y, Sakka N, Ibi M, Nakanishi M, Nakamizo T, Yamakawa K, Shibasaki H, Yamamoto N, Akaike A, Inden M, Kitamura Y, Taniguchi T, Shimohama S: Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions. J Biol Chem. 2004 Mar 12;279(11):10710-9. Epub 2003 Dec 12. Here we report that a combination of 1-methyl-4-phenylpyridinium ion (MPP (+)) or rotenone and proteasome inhibition causes the appearance of alpha-synuclein-positive inclusion bodies. Proteasome inhibition reversed the MAPK dephosphorylation and blocked caspase-3 activation; the neuroprotection was blocked by a p42 and p44 MAPK kinase inhibitor. |
1(0,0,0,1) | Details |
| 15843045 | Tomaselli B, Podhraski V, Heftberger V, Bock G, Baier-Bitterlich G: nucleoside-mediated protection of chemical hypoxia-induced neuronal injuries involves p42/44 MAPK activation. Neurochem Int. 2005 Jun;46(7):513-21. O (2)-sensitive neuronal pheochromocytoma (PC12)-cells, which are widely used as a model system for sympathetic ganglion-like neurons, were subjected to chemical hypoxia induced with rotenone, an inhibitor of mitochondrial complex I. |
1(0,0,0,1) | Details |