Protein Information

Name catalase
Synonyms CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases…

Compound Information

Name HCH
CAS 1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
12038708 Iscan M, Coban T, Cok I, Bulbul D, Eke BC, Burgaz S: The organochlorine pesticide residues and antioxidant enzyme activities in human breast tumors: is there any association?. Breast Cancer Res Treat. 2002 Mar;72(2):173-82.

The levels of some organochlorine pesticides (OCP) s (hexachlorobenzene, HCB, alpha-hexachlorocyclohexane, alpha-HCH, beta-HCH, gamma-HCH, heptachlorepoxide, HE, bis (4-chlorophenyl)-1,1-dichloroethene, p.p'DDE, bis (4-chlorophenyl)-1,1,1-trichloroethane, p.p' DDT and total DDT (E-DDT) and antioxidant enzyme activities namely Cu, Zn superoxide dismutase (SOD), catalase (CAT), selenium-dependent glutathione peroxidase (Se-GSH-Px), total glutathione peroxidase (T-GSH-Px), selenium independent glutathione peroxidase (GSH-Px II), glutathione reductase (GRd), level of reduced glutathione (GSH) and lipid peroxidation (LP), glutathione S-transferase (GST) activity toward several substrates including 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), ethacrynic acid (EAA), 1,2-epoxy-3-(p-nitrophenoxy)-propane (ENPP) were measured in tumor and surrounding tumor free tissues of 24 female breast cancer patients and was evaluated whether there exist any association between the levels of OCPs and antioxidants.
31(0,1,1,1) Details
18940228 Anilakumar KR, Saritha V, Khanum F, Bawa AS: Ameliorative effect of ajwain extract on hexachlorocyclohexane-induced lipid peroxidation in rat liver. Food Chem Toxicol. 2009 Feb;47(2):279-82. Epub 2008 Oct 4.


Results revealed that HCH administration lead to an increase in hepatic lipid peroxidation associated with reduction in, levels of glutathione (GSH), activity of superoxide dismutase (SOD), catalase and glucose-6-phosphate dehydrogenase.
3(0,0,0,3) Details
12364975 Samanta L, Chainy GB: Response of testicular antioxidant enzymes to hexachlorocyclohexane is species specific. Asian J Androl. 2002 Sep;4(3):191-4.


Although the level of H2O2 content increased in response to HCH in both groups, a totally different trend was observed for the activity of the principal H2O2-metabolising enzyme, catalase.
2(0,0,0,2) Details
9467884 Samanta L, Chainy GB: Comparison of hexachlorocyclohexane-induced oxidative stress in the testis of immature and adult rats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1997 Nov;118(3):319-27.


The activity of catalase decreased 6 hr after the pesticide treatment in both the age groups.
1(0,0,0,1) Details
16046044 Srivastava A, Shivanandappa T: Hexachlorocyclohexane differentially alters the antioxidant status of the brain regions in rat. Toxicology. 2005 Oct 15;214(1-2):123-30.


Activities of glutathione peroxidase, glutathione reductase, glutathione-S-transferase and catalase were markedly induced whereas superoxide dismutase was inhibited at higher dose in all the brain regions.
1(0,0,0,1) Details
10790496 Sahoo A, Samanta L, Chainy GB: Mediation of oxidative stress in HCH-induced neurotoxicity in rat. Arch Environ Contam Toxicol. 2000 Jul;39(1):7-12.


Catalase activity decreased throughout the treatment period.
1(0,0,0,1) Details
9704597 Sahoo A, Chainy GB: Acute hexachlorocyclohexane-induced oxidative stress in rat cerebral hemisphere. Neurochem Res. 1998 Aug;23(8):1079-84.


The pesticide elicited decrease in the activities of cytosolic total, CN (-)-sensitive (not at 24 h) and CN-resistant superoxide dismutases; total, Se-dependent and Se-independent glutathione peroxidases; and catalase throughout the measurement period.
1(0,0,0,1) Details
1708174 Barros SB, Simizu K, Junqueira VB: Liver lipid peroxidation-related parameters after short-term administration of hexachlorocyclohexane isomers to rats. Toxicol Lett. 1991 Apr;56(1-2):137-44.


Other parameters studied were liver glucose-6-phosphate dehydrogenase, glutathione peroxidase, glutathione reductase and catalase (CAT) activities.
1(0,0,0,1) Details
7538972 Samanta L, Chainy GB: Hexachlorocyclohexane-induced changes in lipid peroxidation, superoxide dismutase and catalase activities and glutathione content in chick liver. Indian J Exp Biol. 1995 Feb;33(2):131-3.

1(0,0,0,1) Details
10350190 Samanta L, Sahoo A, Chainy GB: Age-related changes in rat testicular oxidative stress parameters by hexachlorocyclohexane. Arch Toxicol. 1999 Mar;73(2):96-107.


In both age-groups of rats, the pesticide elicited a significant decrease in the activities of cytosolic superoxide dismutase (SOD; total and CN (-)-resistant) and catalase, and ascorbic acid content together with an increase in the levels of LPX (both in crude homogenate and subcellular fractions) and H2O2.
1(0,0,0,1) Details
17618397 Elia AC, Dorr AJ, Galarini R: Comparison of organochlorine pesticides, PCBs, and heavy metal contamination and of detoxifying response in tissues of Ameiurus melas from Corbara, Alviano, and Trasimeno Lakes, Italy. Bull Environ Contam Toxicol. 2007 Jun;78(6):463-8. Epub 2007 Jul 7.


Glutathione content and the enzymatic activities of glutathione reductase, glutathione peroxidase, catalase, glutathione S-transferase, and glyoxalase I were examined in gills, liver, and kidneys of each specimen.
1(0,0,0,1) Details
16838206 Wang F, Xu ZR, Sun JH: Effect of HCH contamination of diet on the growth performance and immune and antioxidant ability in growing/finishing pigs. Vet Res Commun. 2006 Aug;30(6):645-54.


Addition of HCH to feedstuff reduced superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GSH-Px) activities in liver, reduced serum catalase (CAT) activity, and increased serum malondialehyde (MDA).
1(0,0,0,1) Details
17569287 Anilakumar KR, Nagaraj NS, Santhanam K: Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by Emblica officinalis gaertn. Indian J Exp Biol. 2007 May;45(5):450-4.


On the other hand, the HCH-induced impairment in hepatic catalase, G-6-PDH and SOD activities were modulated by amla at the 10% level of intake.
1(0,0,0,1) Details
2299401 Saltarelli MD, Yamada K, Coyle JT: Phospholipase A2 and 3H-hemicholinium-3 binding sites in rat brain: a potential second-messenger role for fatty acids in the regulation of high-affinity choline uptake. J Neurosci. 1990 Jan;10(1):62-72.


The involvement of phospholipase A2 (PLA2) and fatty acid release in the regulation of sodium-dependent high-affinity choline uptake in rat brain was assessed in vitro through the use of the specific binding of 3H-hemicholinium-3 (3H-HCh-3).
0(0,0,0,0) Details