Protein Information

Name P60
Synonyms ARHGEF 5; p60; TIM1; TIM; ARHGEF5; GEF 5; GEF5; Guanine nucleotide regulatory protein TIM…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
2424022 Levy JB, Iba H, Hanafusa H: Activation of the transforming potential of p60c-src by a single amino acid change. Proc Natl Acad Sci U S A. 1986 Jun;83(12):4228-32.


The p60 proteins of the transforming mutant src viruses were found to have higher levels of in vitro tyrosine kinase activity than the levels observed with the parental viruses.
3(0,0,0,3) Details
2582236 Iba H, Cross FR, Garber EA, Hanafusa H: Low level of cellular protein phosphorylation by nontransforming overproduced p60c-src. Mol Cell Biol. 1985 May;5(5):1058-66.


Phosphorylation at tyrosine 416 of p60 itself was also extremely low in overproduced p60c-src and high in p60s of transforming mutant viruses.
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3038816 Nakano H, Kobayashi E, Takahashi I, Tamaoki T, Kuzuu Y, Iba H: Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60. J Antibiot. 1987 May;40(5):706-8.

1(0,0,0,1) Details
2463379 Sato M, Kato J, Takeya T: Characterization of partially activated p60c-src in chicken embryo fibroblasts. J Virol. 1989 Feb;63(2):683-8.

The results obtained from protease V8 analysis, tryptic peptide mapping, and fractionation with nonionic detergent indicated that the p60 of each variant was present in two forms in the population of the virus-infected cells; one was phosphorylated on Tyr-416, and the other was phosphorylated on Tyr-527.
Iba, J.
4(0,0,0,4) Details