Protein Information

Name serine threonine protein phosphatase
Synonyms PP6; Serine/threonine protein phosphatase; PPP 6; PPP6; PPP6C; Protein phosphatase 6 catalytic subunit; Serine/threonine protein phosphatase 6; Serine/threonine protein phosphatase catalytic subunit…

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
11533141 Gromada J, Hoy M, Buschard K, Salehi A, Rorsman P: Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G (i2)-dependent activation of calcineurin and depriming of secretory granules. J Physiol. 2001 Sep 1;535(Pt 2):519-32.

The inhibitory effect of somatostatin on exocytosis was mediated by activation of the serine/threonine protein phosphatase calcineurin and was prevented by pretreatment with cyclosporin A and deltamethrin or intracellularly applied calcineurin autoinhibitory peptide.
31(0,1,1,1) Details
10535451 Poulsen CR, Bokvist K, Olsen HL, Hoy M, Capito K, Gilon P, Gromada J: Multiple sites of purinergic control of insulin secretion in mouse pancreatic beta-cells. Diabetes. 1999 Nov;48(11):2171-81.

Inhibition of exocytosis by ATP resulted from G-protein-dependent activation of the serine/threonine protein phosphatase calcineurin and was abolished by cyclosporin A and deltamethrin.
31(0,1,1,1) Details
8866865 Godart H, Ellory JC: KCl cotransport activation in human erythrocytes by high hydrostatic pressure. J Physiol. 1996 Mar 1;491 ( Pt 2):423-34.

The serine/threonine protein phosphatase inhibitors okadaic acid, cantharidin and calyculin A inhibited the stimulatory pressure effect in a dose-dependent manner with half-maximum inhibitory concentrations of 70 nM, 2.5 microM and 3.3 nM, respectively.
In contrast, deltamethrin, a specific protein phosphatase type 2B inhibitor, did not affect the stimulation by pressure, up to a concentration of 10 microM. 5.
1(0,0,0,1) Details