Protein Information

Name klotho
Synonyms KL; Klotho; Klotho peptide; Klotho precursor; Klothos; Klotho peptides; Klotho precursors

Compound Information

Name phosphorus
CAS phosphorus

Reference List

PubMed Abstract RScore(About this table)
19345526 Torres PA: [Origin of the mediacalcosis in kidney failure] . J Mal Vasc. 2009 May;34(3):204-10. Epub 2009 Apr 3.

It is now possible to identify factors clearly favoring the formation of VC: TNF-alpha (which stimulates cell necrosis/apoptosis), CRP, oxidized lipids, AGEs, leptin, inorganic phosphate, high calcium-phosphorus product (CaxPO (4)), calcium, 1,25-OH (2) D (3) and Vitamin D (3), PTHrP (via an intracrine pathway), cyclic AMP, TGF-beta, bone morphogenic protein 2 (BMP2) and factors protective against the formation of VC: magnesium, HDL, inorganic pyrophosphate, albumin, ahsg/fetuin A, osteopontin (OPN), osteoprotegerin (OPG), osteonectin (ON), bone morphogenic protein 7 (BMP7), klotho, PTHrP (via a paracrine pathway), matrix gla protein (MGP), PTH (via Msx2) and vitamin K.
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19295198 Nikolov IG, Mozar A, Drueke TB, Massy ZA: Impact of disturbances of calcium and phosphate metabolism on vascular calcification and clinical outcomes in patients with chronic kidney disease. Blood Purif. 2009;27(4):350-9. Epub 2009 Mar 18.

Hypercalcemia and hyperphosphatemia have long been known to play a major role in the occurrence of vascular and other soft tissue calcification in patients with CKD, together with endocrine disturbances including vitamin D, parathyroid hormone, fibroblast growth factor-23, and klotho.
It remains to be demonstrated in prospective randomized trials whether normalization of serum phosphorus and/or calcium leads to better patient outcome.
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19299893 Taylor JG, Bushinsky DA: Calcium and phosphorus homeostasis. Blood Purif. 2009;27(4):387-94. Epub 2009 Mar 23.

In addition to parathyroid hormone and vitamin D, recently identified factors such as fibroblast growth factors and klotho play an important role in maintaining mineral ion homeostasis.
1(0,0,0,1) Details