Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name piperonyl butoxide
CAS 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
2718172 Clay RJ, Morris JB: Comparative pneumotoxicity of cyclopentadienyl manganese tricarbonyl and methylcyclopentadienyl manganese tricarbonyl. Toxicol Appl Pharmacol. 1989 May;98(3):434-43.

Piperonyl butoxide diminished both the pneumotoxicity and Mn accumulation resulting from CMT or MMT, suggesting both phenomena are due to monooxygenase metabolites.
The pneumotoxic response to either compound was characterized by large increases in lavage albumin and protein content with smaller increases in lactate dehydrogenase levels.
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2173718 Bysani GK, Kennedy TP, Ky N, Rao NV, Blaze CA, Hoidal JR: Role of cytochrome P-450 in reperfusion injury of the rabbit lung. . J Clin Invest. 1990 Nov;86(5):1434-41.

The P-450 inhibitors 8-methoxypsoralen, piperonyl butoxide, and cimetidine markedly decreased lung edema from transvascular fluid flux.
Cimetidine prevented the reperfusion-related increase in lung microvascular permeability, as measured by movement of 125I-albumin from the vascular space into lung water and alveolar fluid.
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1585383 Fujitani T, Ando H, Fujitani K, Ikeda T, Kojima A, Kubo Y, Ogata A, Oishi S, Takahashi H, Takahashi O, et al.: Sub-acute toxicity of piperonyl butoxide in F344 rats. Toxicology. 1992;72(3):291-8.

Rats of the 2.4%-group had increased levels of albumin, cholesterol, urea nitrogen and gamma-glutamyl transpeptidase.
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