| 7250022 |
Dishovski K, Panova I, Uzunov P: [Effect of the organophosphorus compound neguvon on the dopamine content in the rat brain]. Eksp Med Morfol. 1981;20(2):62-6.
The authors found that the phosphororganic pesticide neguvon in a dose of 200 mg/kg of body weight diminished the content of dopamine in the striatum of white rats. This effect was increased after daily administration of the same dose for a period of 5 days. The reactivator of cholinesterase TMB-4 and H-choline blocker tropacine prevented this effect. They discussed the connection between the changes in the content of dopamine and modulating role of presynaptic choline receptors of H- and M- types in the dopaminergic terminals of the striatum. |
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