| 18187247 |
Jhala DD, Chinoy NJ, Rao MV: Mitigating effects of some antidotes on fluoride and arsenic induced free radical toxicity in mice ovary. Food Chem Toxicol. 2008 Mar;46(3):1138-42. Epub 2007 Nov 23.
The effects of oral administration of sodium fluoride (NaF) and/or arsenic trioxide (As (2) O (3)) (5 mg and 0.5 mg/kg body weight, respectively) for 30 days were investigated on free radical induced toxicity in the mouse ovary. The reversibility of the induced effects after withdrawal of NaF+As (2) O (3) treatment and by administration of antioxidant vitamins (C, E) and calcium alone as well as in combination were also studied. The combined treatment of NaF and As (2) O (3) impaired significantly (p <0.001) the production of free radical scavengers such as glutathione and ascorbic acid as well as antioxidant enzymes, namely, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (Cat), thereby increasing ovarian lipid peroxides (LPO) which might have rendered the ovary susceptible to injury. The withdrawal of the combined (NaF and As (2) O (3) for 30 days) treatment caused partial recovery in the ovary, which was more pronounced (p <0.001) by treatment with vitamin C, calcium, or vitamin E alone and in combination. Hence the induced toxicity was transient and reversible. |
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