| 10406149 |
Qingfen T, Xirang G, Weijing Y, Jianduan L, Yingli D, Zhimin H: An experimental study on damage of retina function due to toxicity of carbon disulfide and lipid peroxidation. Acta Ophthalmol Scand. 1999 Jun;77(3):298-301.
PURPOSE: To study the relation between the changes in the electroretinogram and the lipid peroxidation of the retina during the period of retinal damage due to carbon disulfide (CS2). METHODS: To examine the amplitude and latency of a, b waves of the electroretinogram (ERG) and to assay the activities of total superoxide dismutases (TSOD), (EC no. 1.15.1.1), glutathione peroxidase (GSH-Px) (EC no.1.11.1.9) and malondialdehyed (MDA) in the retina of animals with experimental CS2 toxic retinopathy. RESULTS: The b wave amplitude (161+/-51 microv) of the animals exposed to CS2 for 3 weeks was significantly lower than that of the controls (310+/-93 microv) (p <0.05). TSOD (30+/-5 Nu/mg) in the retinal tissues exposed was lower than that (38+/-8 Nu/mg) (p <0.05) in the controls and MDA (7+/-2 nmol/mg) in the exposed was higher than that (4+/-1 nmol/mg) (p <0.05) in the controls at a concentration of CS2 1000 mg/m3. Analyzed with the correlation coefficient, there was a significant positive correlation between the amplitude changes of ERG b wave and TSOD (p <0.001) and a remarkable negative correlation between the amplitude changes of ERG b wave and MDA (p <0.05) in the animals' exposed retinal tissues. CONCLUSION: The present studies indicated that the damaged function of early CS2 toxic retinopathy was possibly associated with lipid peroxidation. |
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