| ID | 44 |
|---|---|
| Name | calcium channel (protein family or complex) |
| Synonyms | calcium channel |
| ID | 183 |
|---|---|
| Name | lindane |
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 7680676 | Meera P, Tripathi O, Kamboj KK, Rao PR: Role of in biphasic immunomodulation by gamma-HCH (lindane) in mice. Immunopharmacol Immunotoxicol. 1993 Jan;15(1):113-29. gamma-HCH (Lindane) is reported to cause a biphasic immunomodulation-stimulation followed by suppression-after oral administration in mice. Role of in this biphasic immunomodulation was assessed after 4, 12 and 24 wks of gamma-HCH administration. 45Ca-uptake was enhanced during the initial immunostimulation followed by decrease concomitant with immunosuppression. Lymphocyte proliferation was inhibited during both the phases of immune response by a calcium channel blocker, and by trifluoperazine, a calmodulin inhibitor. These findings show an impairment of homeostasis in lymphocytes culminating into the biphasic immunomodulatory effects of gamma-HCH. |
1(0,0,0,1) |