Protein Information

ID 58
Name N acetyltransferase
Synonyms AAC 2; NAT2; AAC2; ARY 2; ARY2; Arylamide acetylase 2; Arylamine N acetyltransferase 2; N acetyltransferase…

Compound Information

ID 183
Name lindane
CAS (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane

Reference

PubMed Abstract RScore(About this table)
1699720 Moreteau B, Chaminade N: The effects of lindane poisoning on N-acetyldopamine and N-acetyl 5-hydroxytryptamine concentrations in the brain of Locusta migratoria L. Ecotoxicol Environ Saf. 1990 Aug;20(1):115-20.
High-performance liquid chromatography with electrochemical detection was used to measure N-acetyldopamine and N-acetyl 5-hydroxytryptamine in the cerebral ganglia of the African migratory locust, Locusta migratoria (fifth instar) exposed to lindane, a chlorinated insecticide. Locusts were poisoned by this insecticide in order to assess the effects of this neuroactive compound on these acetylated metabolites levels. Relatively low concentrations of N-acetyldopamine were observed in the cerebral ganglia. Incubation of ganglia resulted in increased concentrations of N-acetyldopamine and N-acetyl 5-hydroxytryptamine. Lindane significantly reduces N-acetyldopamine and N-acetyl 5-hydroxytryptamine levels in the cerebral ganglia. These results can be correlated with a decrease in N-acetyltransferase activity.
1(0,0,0,1)