| 10325624 |
Xu H, He X, Xie Z, He F: [Blocking effects of dimethoate on acetylcholine receptor channels] . Wei Sheng Yan Jiu. 1997 May;26(3):154-8.
The patch-clamp technique was used to study the inhibitory effect of dimethoate, an organophosphrous pesticide, on the membrane of embryoinc Xenopus musle cells in culture. Using whole-cell clamp and cell-attached clamp, we found that the direct inhibitory effects of dimethoate was evidenced on both miniature end-plate currents (MEPC) and single channel currents. Dimethoate increased the amplitude and frequency of MEPC at a lower concentration (21.6 mumol/L) while both decreased at a higher concentration (237 mumol/L). The dimethoate at a concentration of 146 mumol/L shortened the opening time and decreased the opening probability of the single channel. The results show that dimethoate is an AChR channel blocker. |
31(0,1,1,1) |