| 1420286 |
Alomar Y, Negre-Salvayre A, Levade T, Valdiguie P, Salvayre R: Oxidized HDL are much less cytotoxic to lymphoblastoid cells than oxidized LDL. Biochim Biophys Acta. 1992 Oct 30;1128(2-3):163-6.
The possible effect of oxidized HDL was investigated on lymphoblastoid cells, in comparison to the cytotoxic effect of oxidized LDL. Oxidation of HDL was promoted by UV-C irradiation, or by copper ion (5 microM) or the combination of the two treatments. HDL extensively treated by UV-C for 20 h did not exhibit any cytotoxic effect on cultured lymphoblastoid cells even at a concentration of 500 micrograms apolipoprotein A-I/ml. In contrast to UV-treated (2 h) LDL, which were highly cytotoxic (already at a concentration of 100 micrograms apolipoprotein B/ml), HDL treated by copper or copper + UV were oxidized, as shown by TBARS formation and PUFA content decrease, but were slightly cytotoxic. |
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