| ID | 291 |
|---|---|
| Name | glycine receptors (protein family or complex) |
| Synonyms | Glycine receptor; Glycine receptors |
| ID | 336 |
|---|---|
| Name | strychnine |
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 8713181 | Chiba C, Saito T: Responses mediated by excitatory and inhibitory amino acid receptors in solitary spiking cells from normal newt retina. Mol Cell Neurosci. 2001 Feb;17(2):354-63. Whole-cell currents activated by kainate (KA), alpha-amino-3--5-methyl-4-isoxazole- (AMPA), and were recorded from spiking cells enzymatically dissociated from adult newt retina. Most spiking cells responded to both AMPA and KA. KA tended to be a more potent agonist for them than AMPA. The reversal potential of both AMPA and KA responses was about -7 mV; this value was similar to that (about -5 mV) of response. AMPA- and KA-induced currents may be carried by monovalent cations, such as Na+, because their reversal potentials were sensitive to external Na+. About half of the spiking cells examined responded to mixtures of and Extracellular Mg2+ blocked completely the response to plus in spiking cells held at negative membrane potentials, but not at positive membrane potentials. Almost all spiking cells responded to the inhibitory amino acids and Dose-dependent desensitization was observed in both and responses. Currents activated by and were carried by Cl-. Bicuculline and strychnine strongly suppressed the responses to and respectively, suggesting the existence of GABAA receptors and conventional glycine receptors in the spiking cells. |
81(1,1,1,1) |