| 7475222 |
Ueno S, Nabekura J, Ishibashi H, Akaike N, Mori T, Shiga M: Photolysis of a newly synthesized caged glycine activates the glycine receptor of rat CNS neurons. J Neurophysiol. 1995 Jul;74(1):1-11.
The functions of 12 different newly synthesized caged glycines were examined on strychnine-sensitive glycine receptors on rat hypothalamic neurons using photochemical and physiological methods. Quantitative analysis of Cl- current induced by photolyzed glycines revealed N-[1-(2-nitrophenyl) ethylcarbonoxyl] glycine (N4-caged glycine) to be the most effectively photolyzed. The current amplitude induced by photolyzed N4-caged glycine was almost the same as that induced by normal glycine. We propose N-[1-(2-nitrophenyl) ethylcarbonoxyl] to be a useful photolabile moiety for new caged neurotransmitters. |
32(0,1,1,2) |