| 15926343 |
Menzikov SA, Menzikova OV: [Effect of glycine and strychnine on Cl (-)-activated Mg2+-ATPase from bream brain microsomes (Abamis brama L.)]. Izv Akad Nauk Ser Biol. 2001 Nov-Dec;(6):760-3.
The effect of glycine and strychnine on Mg2+-ATPase from the microsomal fraction of the bream (Abramis brama L.) brain was studied. The glycine in the concentration range 10 (-7)-10 (-4) M activates the enzyme. The effect of glycine on Mg2+-ATPase is obviated by 100 microM strychnine. The strychnine in the concentration range 5-90 microM activates the basal Mg2+-ATPase but decreases the effect of the enzyme activation by 10 (-4) M glycine. The effect of Cl- on Mg2+-ATPase depends on the substrate concentration (Mg2+-ATP) and is not observed in the presence of 100 microM strychnine. A receptor-dependent pathway of glycine and strychnine action on Cl (-)-activated Mg2+-ATPase from bream brain microsomes is proposed. |
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