| 7817791 |
Saransaari P, Oja SS: Characterization of sodium-independent beta-alanine binding to cerebral cortical membranes from 7-day-old and adult mice. Int J Dev Neurosci. 1994 Aug;12(5):491-7.
The sodium-independent binding of beta-alanine to cerebral cortical membranes from adult (3- and 12-month-old) and developing (7-day-old) mice was characterized for the first time. The binding was saturable in each age group, consisting of only one component. The affinity for beta-alanine was highest and the number of available binding sites greatest in young animals. The binding was not affected by strychnine, but inhibited by beta-alanine itself, glycine, L-alanine and L-serine, the IC50 values being lower in immature mice. Glycine was shown to be a competitive inhibitor. The binding was also inhibited, albeit only in adults, by N-methyl-D-aspartate receptor antagonists acting at the glycine modulatory site and by some GABAergic substances. It is concluded that even though beta-alanine may possess binding sites of its own, particularly in the immature cerebral cortex, beta-alanine could at least partly bind to strychnine-insensitive glycine sites in the N-methyl-D-aspartate receptor complex. |
32(0,1,1,2) |