Protein Information

ID 65
Name NMDA receptor (protein family or complex)
Synonyms Glutamate [NMDA] receptor; Glutamate [NMDA] receptors; N methyl D aspartate receptor; N methyl D aspartate receptors; NMDA receptor; NMDA receptors

Compound Information

ID 336
Name strychnine
CAS strychnidin-10-one

Reference

PubMed Abstract RScore(About this table)
12960774 Meier J, Schmieden V: Inhibition of alpha-subunit glycine receptors by quinoxalines. Neuroreport. 2003 Aug 6;14(11):1507-10.
Quinoxalines are widely used compounds in electrophysiological studies to separate excitatory and inhibitory neurotransmission mediated by the strychnine-insensitive and strychnine-sensitive glycine receptor (NMDA, GlyR), respectively. We report here, that the quinoxaline NBQX is a potent antagonist of homo-oligomeric alpha1- and alpha2-subunit glycine receptors expressed in Xenopus laevis oocytes. NBQX elicited half-maximal inhibition of glycine evoked currents at a concentration of about 5 microM. DNQX and CNQX were found to be 5-fold and 20-fold less efficient than NBQX. At oocytes expressing alpha1beta2 subunit GABAA receptors the quinoxalines tested showed no significant inhibition of GABA responses up to a concentration of 100 microM. Our data indicates that these quinoxalines applied at concentrations sufficient to block NMDA receptor also attenuate GlyR responses.
1(0,0,0,1)