| 12046990 |
Iwahori Y, Ikegaya Y, Matsuki N: Hyperpolarization-activated current I (h) in nucleus of solitary tract neurons: regional difference in serotonergic modulation. Jpn J Pharmacol. 2002 Apr;88(4):459-62.
The nucleus of solitary tract (NTS) contains diverse neural circuits responsible for basic vital functions. We examined the effect of serotonin (5-HT) on hyperpolarization-activated current (I (h)) in neurons acutely isolated from caudal, medial and rostral parts of the NTS. Caudal and medial NTS neurons showed a large amplitude of I (h) compared with rostral neurons. In these neurons, perfusion with 5-HT potentiated Ih amplitude in a concentration-dependent manner. The effect of 5-HT was blocked by NAN-190, a 5-HT1A receptor antagonist. Thus, 5-HT1A receptors may regulate I (h) channel activity in caudal and medial NTS neurons. |
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