Protein Information

ID 4734
Name 5 hydroxytryptamine receptor (protein family or complex)
Synonyms 5 Hydroxytryptamine receptor; 5 Hydroxytryptamine receptors; 5 hydroxytryptamine 3 receptor; 5 hydroxytryptamine 3 receptors; serotonin receptor; serotonin receptors

Compound Information

ID 1819
Name piperazine
CAS piperazine

Reference

PubMed Abstract RScore(About this table)
16256082 Gatch MB: Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine. Brain Res. 2005 Nov 16;1062(1-2):161-5. Epub 2005 Oct 26.
Rats were trained to discriminate the 5-HT agonist m-chlorophenylpiperazine (mCPP, 1 mg/kg, i.p.) from saline. Ethanol (0.1 to 1 g/kg, i.p.) partially substituted for the discriminative stimulus effects of 1 mg/kg mCPP. Methysergide (10 mg/kg, i.p.), a 5-HT (1/2) receptor antagonist, blocked the ability of ethanol (1 g/kg) to substitute for mCPP. The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol.		 1(0,0,0,1)