Lipoxygenase (protein family or complex)

General Information (Source: NCBI Gene,UniProt)

Text mining Term Lipoxygenase (protein family or complex)
UniProt ID LOXA_PSEAE
Name Arachidonate 15-lipoxygenase
15-LOX
Gene Names loxA
Taxonomy Pseudomonas aeruginosa PAO1

General annotation

Function Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid (HpETE) which is rapidly reduced to hydroxyeicosatetraenoic acid (HETE). Could act on exogenous human-derived substrates to potentially modulate the local inflammatory responses during P.aeruginosa infections.
Subcellular location Periplasm. Secreted, extracellular space. Note=Periplasmic with some activity further secreted to the extracellular milieu.

Gene Ontology

GO:0005615 extracellular space CC
GO:0042597 periplasmic space CC
GO:0050473 arachidonate 15-lipoxygenase activity MF
GO:0046872 metal ion binding MF

Sequence

>gi|15596366|ref|NP_249860.1| unnamed protein product [Pseudomonas aeruginosa PAO1]
MKRRSVLLSGVALSGTALANDSIFFSPLKYLGAEQQRSIDASRSLLDNLIPPSLPQYDNLAGKLARRAVL
TSKKLVYVWTENFGNVKGVPMARSVPLGELPNVDWLLKTAGVIVELIVNFVASLPASAAAQFERIATGLS
GDLEAARQVHEALLEEAKNDPAAAGSLLLRFTELQTRVIAILTRVGLLVDDILKSASNLVTQRGQGDGLN
RFRAVFGTLRLPEVADSFRDDEAFAYWRVAGPNPLLIRRVDALPANFPLGEEQFRRVMGADDSLLEAAAS
RRLYLLDYAELGKLAPSGAVDKLLTGTGFAYAPIALFALGKDRARLLPVAIQCGQDPATHPMFVRPAESE
SDLYWGWQMAKTVVQVAEENYHEMFVHLAQTHLVSEAFCLATQRTLAPSHPLHVLLAPHFEGTLFINEGA
ARILLPSAGFIDVMFAAPIQDTQATAGGNRLGFDFYRGMLPESLKARNVDDPLALPDYPYRDDGLLVWNA
IRQWAADYVAVYYASDGDVTADVELAAWVGEVIGSGKVAGFRPITGRSQLVEVLTMVIFTASAQHAAVNF
PQPSMMTYAPAICAMSAAPAPDSPSGKSEADWLKMMPPTLVALEKVNIYHLLGSVYHGRLGDYRQTGFPY
APVFSDRRVTASGGPLERFQARLKEVEATIRTRNQARRRPYEYLLPSRIPASTNI

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq NP_249860.1
Pfam PF00305