kynurenine aminotransferase I

General Information (Source: NCBI Gene,UniProt)

Text mining Term kynurenine aminotransferase I
UniProt ID KAT1_RAT
Name Kynurenine aminotransferase I
Glutamine--phenylpyruvate transaminase
Glutamine transaminase K
Kynurenine--oxoglutarate transaminase I
Kynurenine--oxoglutarate transaminase 1, mitochondrial
GTK
Cysteine-S-conjugate beta-lyase
KATI
Gene Names Ccbl1
Synonyms:Kat
Taxonomy Rattus norvegicus

General annotation

Function Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity).
Subcellular location Isoform 2: Cytoplasm. Isoform 1: Mitochondrion matrix.

Gene Ontology

GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity MF
GO:0070189 kynurenine metabolic process BP
GO:0047804 cysteine-S-conjugate beta-lyase activity MF
GO:0047316 glutamine-phenylpyruvate transaminase activity MF
GO:0030170 pyridoxal phosphate binding MF
GO:0005759 mitochondrial matrix CC
GO:0016212 kynurenine-oxoglutarate transaminase activity MF

Sequence

>gi|148356231|ref|NP_001013182.3| kynurenine--oxoglutarate transaminase 1, mitochondrial [Rattus norvegicus]
MFRSAAALSVHLMWPLWGRKAGASLTRCLHQSLTMTKRLQARRLDGIDQNLWVEFGKLTKEYDVVNLGQG
FPDFSPPDFATQAFQQATSGNFMLNQYTRAFGYPPLTNVLASFFGKLLGQEMDPLTNVLVTVGAYGALFT
AFQALVDEGDEVIIMEPAFDCYEPMTMMAGGCPVFVTLKPSPAPKGKLGASNDWQLDPAELASKFTPRTK
ILVLNTPNNPLGKVFSRMELELVANLCQQHDVVCISDEVYQWLVYDGHQHVSIASLPGMWDRTLTIGSAG
KSFSATGWKVGWVMGPDNIMKHLRTVHQNSIFHCPTQAQAAVAQCFEREQQHFGQPSSYFLQLPQAMELN
RDHMIRSLQSVGLKLWISQGSYFLIADISDFKSKMPDLPGAEDEPYDRRFAKWMIKNMGLVGIPVSTFFS
RPHQKDFDHYIRFCFVKDKATLQAMDERLRKWKELQP

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Database Cross Reference

Ensembl Gene
UniGene Rn.110564
PDB
RefSeq NP_001013182.3
Pfam PF00155