| Text mining Term | cystathionine beta synthase |
|---|---|
| UniProt ID | CBS_RAT |
| Name |
Serine sulfhydrase Cystathionine beta-synthase Hemoprotein H-450 Beta-thionase |
| Gene Names |
Cbs
|
| Taxonomy | Rattus norvegicus |
| Function |
Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury. |
|---|---|
| Subcellular location |
Nucleus (By similarity). Cytoplasm. |
| GO:0019343 | cysteine biosynthetic process via cystathionine | BP |
| GO:0070814 | hydrogen sulfide biosynthetic process | BP |
| GO:0030170 | pyridoxal phosphate binding | MF |
| GO:0071456 | cellular response to hypoxia | BP |
| GO:0019346 | transsulfuration | BP |
| GO:0006535 | cysteine biosynthetic process from serine | BP |
| GO:0004122 | cystathionine beta-synthase activity | MF |
| GO:0005625 | soluble fraction | CC |
| GO:0043066 | negative regulation of apoptotic process | BP |
>gi|158186659|ref|NP_036654.2| cystathionine beta-synthase [Rattus norvegicus] MPSGTSQCEDGSAGCPQDLEVQPEKGQLEKGASGDKERVWISPDTPSRCTWQLGRPMADSPHYHTVPTKS PKILPDILRKIGNTPMVRINRISKNAGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERAGTLKPGDTII EPTSGNTGIGLALAAAVKGYRCIIVMPEKMSMEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNE IPNSHILDQYRNASNPLAHYDDTAEEILQQCDGKVDMLVASAGTGGTITGIARKLKEKCPGCKIIGVDPE GSILAEPEELNQTEQTAYEVEGIGYDFIPTVLDRAVVDRWFKSNDDDSFAFARMLISQEGLLCGGSSGSA MAVAVKAAQELKEGQRCVVILPDSVRNYMSKFLSDKWMLQKGFMKEELSVKRPWWWHLRVQELSLSAPLT VLPTVTCEHTIAILREKGFDQAPVVNESGAILGMVTLGNMLSSLLAGKVRPSDEVCKVLYKQFKPIHLTD TLGMLSHILEMDHFALVVHEQIQYRNNGVSSKQLMVFGVVTAIDLLNFVAAREQTRK |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.87853 |
| PDB | |
| RefSeq |
NP_036654.2 |
| Pfam |
PF00571 PF00291 |