tissue plasminogen activator

General Information (Source: NCBI Gene,UniProt)

Text mining Term tissue plasminogen activator
UniProt ID TPA_RAT
Name tPA
Tissue-type plasminogen activator
Tissue-type plasminogen activator chain B
t-PA
Tissue-type plasminogen activator chain A
t-plasminogen activator
Gene Names Plat
Taxonomy Rattus norvegicus

General annotation

Function Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
Subcellular location Secreted, extracellular space.

Gene Ontology

GO:0048167 regulation of synaptic plasticity BP
GO:0035249 synaptic transmission, glutamatergic BP
GO:0043434 response to peptide hormone stimulus BP
GO:0051384 response to glucocorticoid stimulus BP
GO:0048514 blood vessel morphogenesis BP
GO:0051591 response to cAMP BP
GO:0006508 proteolysis BP
GO:0005615 extracellular space CC
GO:0045202 synapse CC

Sequence

>gi|42476137|ref|NP_037283.2| tissue-type plasminogen activator precursor [Rattus norvegicus]
MKGELLCVLLLCGVAFTLPDQGIHRRFRRGARSYRATCRDEQTQTTYQQHQSWLRPMLRGNRVEYCRCNS
GLAQCHSVPVRSCSEPRCFNGGTCQQALYFSDFVCQCPDGFVGKRCDIDTRATCFEGQGITYRGTWSTAE
NGAECINWNSSALSQKPYSARRPNAIKLGLGNHNYCRNPDRDVKPWCYVFKAGKYTTEFCSTPACPKGPT
EDCYVGKGVTYRGTHSFTTSKASCLPWNSMILIGKTYTAWRANSQALGLGRHNYCRNPDGDAKPWCHVMK
DRKLTWEYCDMSPCSTCGLRQYKQPQFRIKGGLFTDITSHPWQAAIFVKNKRSPGERFLCGGVLISSCWV
LSAAHCFVERFPPHHLKVVLGRTYRVVPGEEEQTFEIEKYIVHKEFDDDTYDNDIALLQLRSDSSQCAQE
SSSVGTACLPDPDVQLPDWTECELSGYGKHEASSPFFSDRLKEAHVRLYPSSRCTSQHLFNKTITSNMLC
AGDTRTGGNQDVHDACQGDSGGPLVCMIDKRMTLLGIISWGLGCGQKDVPGIYTKVTNYLNWIQDNMKQ

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000025763
UniGene Rn.107102
PDB
RefSeq NP_037283.2
Pfam PF00089
PF00051
PF00008
PF00039