granulocyte macrophage colony stimulating factor

General Information (Source: NCBI Gene,UniProt)

Text mining Term granulocyte macrophage colony stimulating factor
UniProt ID CSF2_RAT
Name Colony-stimulating factor
GM-CSF
Granulocyte-macrophage colony-stimulating factor
CSF
Gene Names Csf2
Synonyms:Csfgm
Taxonomy Rattus norvegicus

General annotation

Function Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes (By similarity).
Subcellular location Secreted.

Gene Ontology

GO:0042116 macrophage activation BP
GO:0008083 growth factor activity MF
GO:0050673 epithelial cell proliferation BP
GO:0005125 cytokine activity MF
GO:0005615 extracellular space CC
GO:0042045 epithelial fluid transport BP
GO:0005129 granulocyte macrophage colony-stimulating factor receptor binding MF
GO:0097028 dendritic cell differentiation BP
GO:0006955 immune response BP
GO:0045651 positive regulation of macrophage differentiation BP
GO:0071222 cellular response to lipopolysaccharide BP

Sequence

>gi|109490726|ref|XP_001074265.1| PREDICTED: granulocyte-macrophage colony-stimulating factor [Rattus norvegicus]
MWLQNLLFLGIVVYSFSAPTRSPNPVTRPWKHVDAIKEALSLLNDMRALENEKNEDVDIISNEFSIQRPT
CVQTRLKLYKQGLRGNLTKLNGALTMIASHYQTNCPPTPETDCEIEVTTFEDFIKNLKGFLFDIPFDCWK
PVQK

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000032333
UniGene Rn.44285
PDB
RefSeq XP_001074265.1
XP_340800.3
Pfam PF01109