Rhodanese

General Information (Source: NCBI Gene,UniProt)

Text mining Term Rhodanese
UniProt ID THTR_RAT
Name Rhodanese
Thiosulfate sulfurtransferase
Gene Names Tst
Taxonomy Rattus norvegicus

General annotation

Function Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity). Involved in the formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity.
Subcellular location Mitochondrion matrix.

Gene Ontology

GO:0035928 rRNA import into mitochondrion BP
GO:0008097 5S rRNA binding MF
GO:0005759 mitochondrial matrix CC
GO:0016226 iron-sulfur cluster assembly BP
GO:0004792 thiosulfate sulfurtransferase activity MF

Sequence

>gi|57528682|ref|NP_036940.1| thiosulfate sulfurtransferase [Rattus norvegicus]
MVHQVLYRALVSTKWLAESIRSGKVGPSLRVLDASWYSPGTRQARKEYQERHVPGASFFDIEECRDTTSP
YEMMLPSEAHFGDYVGNLGISNDTHVVVYDGDDLGSFYAPRVWWMFRVFGHRTVSVLNGGFRNWLKEGHP
VTSEPSRPEPAVFKATLNRSLLKTYEQVLENLQSKRFQLVDSRAQGRYLGTQPEPDAVGLDSGHIRGSVN
VPFMNFLTEDGFEKSPEELRAIFQDKKVDLSQPLIATCRKGVTACHIALAAYLCGKPDVAVYDGSWSEWF
RRAPPETRVSQGKSGKA

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Database Cross Reference

Ensembl Gene ENSRNOT00000050511
UniGene Rn.6360
PDB
RefSeq NP_036940.1
Pfam PF00581