histamine H2 receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term histamine H2 receptor
UniProt ID HRH2_RAT
Name H2R
Gastric receptor I
Histamine H2 receptor
HH2R
Gene Names Hrh2
Taxonomy Rattus norvegicus

General annotation

Function The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0004969 histamine receptor activity MF
GO:0016021 integral to membrane CC
GO:0005886 plasma membrane CC

Sequence

>gi|94400879|ref|NP_037097.3| histamine H2 receptor [Rattus norvegicus]
MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLL
VLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLV
FIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIARE
QAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANS
ALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELT
HPQGNPIR

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.138113
PDB
RefSeq NP_037097.3
Pfam PF00001