fibrillarin

General Information (Source: NCBI Gene,UniProt)

Text mining Term fibrillarin
UniProt ID FBRL_NEUCR
Name rRNA 2'-O-methyltransferase fibrillarin
Gene Names
Taxonomy Neurospora crassa OR74A

General annotation

Function Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity).
Subcellular location Nucleus, nucleolus (By similarity). Note=Fibrillar region of the nucleolus (By similarity).

Gene Ontology

GO:0006364 rRNA processing BP
GO:0008033 tRNA processing BP
GO:0030529 ribonucleoprotein complex CC
GO:0003723 RNA binding MF
GO:0005730 nucleolus CC
GO:0008168 methyltransferase activity MF

Sequence

>gi|85103252|ref|XP_961478.1| fibrillarin [Neurospora crassa OR74A]
MGFERGGRGGARGGGRGGFGGDRGGRGGARGGSRGGFGGGRGGGAPRGRGGPRGGGRGGATRGRGGARGG
AKGGAAGKKVIVEPHRHKGVFVARGGKEDLLATVNLVPGESVYGEKRISVENASKEEGGASTKTEYRIWN
PFRSKLAAGILGGLETIYMKPGSKVLYLGAASGTSVSHVADIVGPTGSVYAVEFSHRSGRDLINMATRRT
NVIPIVEDARKPMAYRMLLPMVDVIFADVAQPDQARIVGINAKLFLKQGGGLLISIKASCIDSTAPPEQV
FASEVQKLREDKFFPKEQLTLEPYERDHAMVSCVYQQKEFVDN

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Database Cross Reference

Ensembl Gene
UniGene Ncr.7725
PDB
RefSeq XP_961478.1
Pfam PF01269