homeobox

General Information (Source: NCBI Gene,UniProt)

Text mining Term homeobox
UniProt ID HMSH_DROME
Name Muscle segmentation homeobox
Protein msh
Protein drop
Gene Names Dr
Synonyms:msh
Taxonomy Drosophila melanogaster

General annotation

Function Plays a key role in the specification of proneural and promuscular cluster formation. Required for the specification of dorsal and lateral muscle progenitor cells.
Subcellular location Nucleus.

Gene Ontology

GO:0007450 dorsal/ventral pattern formation, imaginal disc BP
GO:0007476 imaginal disc-derived wing morphogenesis BP
GO:0007419 ventral cord development BP
GO:0007485 imaginal disc-derived male genitalia development BP
GO:0007420 brain development BP
GO:0043565 sequence-specific DNA binding MF
GO:0035222 wing disc pattern formation BP
GO:0003700 sequence-specific DNA binding transcription factor activity MF
GO:0021782 glial cell development BP
GO:0007517 muscle organ development BP
GO:0005634 nucleus CC
GO:0007400 neuroblast fate determination BP
GO:0035309 wing and notum subfield formation BP
GO:0042659 regulation of cell fate specification BP
GO:0007398 ectoderm development BP

Sequence

>gi|81175174|sp|Q03372.2|HMSH_DROME RecName: Full=Muscle segmentation homeobox; AltName: Full=Protein drop; AltName: Full=Protein msh
MLKLSPASMTVTGLRQTMTSPTVPPSSNTPAGNLIITSSSSNSGSNSGSNMSSGNMTSSNLTNLSPSHPA
GLNALASPTSPSALLLAHQQHLLQQHQQHQQQQQQQQQAAALQLAAVHPPAHHLHKTTSRLSNFSVASLL
ADTRPRTPPNQAADGPQNLTSSAATSPISQASSTPPPPPASAAAQVPANTFHPAAVAHHAHLLQAAHAAA
AAHAQHQAMAAQLRQQQQQADARANSPPASTSSTPSSTPLGSALGSQGNVASTPAKNERHSPLGSHTDSE
LEYDEEMLQDHEADHDEEEDSIVDIEDMNADDSPRSTPDGLDGSGKSLESPHGPPPGSHMQSTILSPAAL
ASGHVPIRPTPFSALAAAAVAWTGMGGGVPWPGTRQMPPFGPPGMFPGAGFGGDANEPPRIKCNLRKHKP
NRKPRTPFTTQQLLSLEKKFREKQYLSIAERAEFSSSLRLTETQVKIWFQNRRAKAKRLQEAEIEKIKMA
ALGRGAPGAQWAMAGYFHPSLMHLG

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.1455
PDB
RefSeq NP_477324.1
Pfam PF00046