Protein Information

Name cholesterol esterase
Synonyms BAL; LIPA; Sterol esterase; Lysophospholipase; BSDL; BSSL; Bile salt activated lipase; Bile salt stimulated lipase…

Compound Information

Name chlorpyrifos
CAS

Reference List

PubMed Abstract RScore(About this table)
16449251 Quistad GB, Liang SN, Fisher KJ, Nomura DK, Casida JE: Each lipase has a unique sensitivity profile for organophosphorus inhibitors. Toxicol Sci. 2006 May;91(1):166-72. Epub 2006 Jan 31.

In an overview, inhibition of 28 serine hydrolases (including lipases) by eight OPs (chlorpyrifos oxon, diazoxon, paraoxon, dichlorvos, and four nonpesticides) showed that brain acetylcholinesterase is usually less sensitive than butyrylcholinesterase, liver esterase, cholesterol esterase, and KIAA1363.
33(0,1,1,3) Details
16243304 Casida JE, Quistad GB: Serine hydrolase targets of organophosphorus toxicants. Chem Biol Interact. 2005 Dec 15;157-158:277-83. Epub 2005 Oct 21.

The toxicological relevance of known secondary OP targets is established mainly from observations with humans (butyrylcholinesterase and neuropathy target esterase-lysophospholipase) and studies with mice (cannabinoid CB1 receptor, carboxylesterase, lysophospholipase and platelet activating factor acetylhydrolase) and hen eggs (arylformamidase or kynurenine formamidase).
Pesticides most commonly shown to inhibit these targets in experimental vertebrates are chlorpyrifos and tribufos.
1(0,0,0,1) Details