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chlorpyrifos

Identification (Source:EPA,EU)

ID	202
Name	chlorpyrifos
CAS	2921-88-2
IUPAC
Inchi	InChI=1S/C9H11Cl3NO3PS/c1-3-14-17(18,15-4-2)16-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3
CIPAC	221
EPA Code	059101
Formula	C9H11Cl3NO3PS
SMILES	Clc1c(OP(=S)(OCC)OCC)nc(Cl)c(Cl)c1
Status	Approved

Classification

Mode of Action	Non-systemic with contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
Pesticide Type	Insecticide
Chemical Group	Organophosphate
Classification	pyridine organothiophosphate insecticides organothiophosphate acaricides organothiophosphate nematicides heterocyclic organothiophosphate insecticides organothiophosphate insecticides

Properties (Source:PubChem)

Molecular Weight	350.89
Physical State	White to brown coloured crystals
AlogP	4.599
H-Bond Donor	0
H-Bond Acceptor	5
Surface Area	307.25
Polar Surface Area	82.48

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Chronic	96 hour	NOEC, growth	0.043 mg l-1
Algae	Acute	72 hour	EC50, growth	0.48 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.00004 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.0046 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.0001 mg l-1
Birds	Acute		LD50	13.3 mg kg-1
Birds	Short term dietary		LC50/LD50	203 ppm
Earthworms	Acute	14 day	LD50	129 mg kg-1
Earthworms	Chronic	14 day	NOEC, reproduction	12.7 mg kg-1
Fish	Acute	96 hour	LC50	0.0013 mg l-1
Fish	Chronic	21 day	NOEC	0.00014 mg l-1
Honeybees	Acute	48 hour	LD50	0.059 μg bee-1
Mammals	Acute oral		LD50	64 mg kg-1
Mammals	Short term dietary		NOEL	1 mg kg-1
Sediment dwelling organisms	Acute	96 hour	LC50	0.00002 mg l-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	0.0001 mg kg-1
	Bio-concentration factor		BCF	1374
	Bio-concentration factor		CT50	2.5 days

Related targets

Target Name	RScore (About this table)
Acetylcholinesterase	11156(95,177,236,801)	Details
cholinesterase	7651(63,124,171,546)	Details
cytochrome P450 (protein family or complex)	1322(11,23,25,72)	Details
P glycoprotein	541(6,7,9,21)	Details
Paraoxonase	1054(5,10,49,309)	Details
adenylate cyclase	437(5,6,6,7)	Details
CYP3A4	540(4,9,11,60)	Details
adenylyl cyclase	478(4,8,11,23)	Details
acetylcholine receptor (protein family or complex)	388(3,7,8,23)	Details
CYP2B6	361(3,6,8,21)	Details
albumin	369(3,5,9,49)	Details
caspase 3	320(3,5,7,10)	Details
5HT transporter	299(3,4,5,24)	Details
neurotrophin	292(3,4,6,12)	Details
p38	255(3,3,4,10)	Details
kinesin	207(2,3,5,7)	Details
Nerve growth factor	201(2,3,3,11)	Details
CB1 receptor	198(2,3,3,8)	Details
AP 1 (protein family or complex)	168(2,2,3,3)	Details
beta adrenoceptors (protein family or complex)	165(2,2,2,5)	Details
basic fibroblast growth factor	162(2,2,2,2)	Details
glutathione S transferase	248(1,5,8,33)	Details
neurotoxic esterase	230(1,5,7,20)	Details
ERK1	178(1,4,4,8)	Details
glial fibrillary acidic protein	167(1,2,9,22)	Details
catalase	144(1,2,6,14)	Details
ChAT	135(1,2,2,25)	Details
Egasyn	126(1,2,2,16)	Details
alkaline phosphatase	123(1,2,3,8)	Details
CYP1A1	122(1,2,3,7)	Details
Fatty acid amide hydrolase	122(1,2,2,12)	Details
C18	110(1,1,3,20)	Details
protein kinase C (protein family or complex)	101(1,1,3,11)	Details
lipase	99(1,1,1,19)	Details
GRK2	92(1,1,2,7)	Details
alpha tubulin	85(1,1,1,5)	Details
ace 1	84(1,1,1,4)	Details
cAMP response element binding protein	84(1,1,1,4)	Details
hormone receptors	83(1,1,1,3)	Details
glutamate receptors (protein family or complex)	83(1,1,1,3)	Details
hexokinase	82(1,1,1,2)	Details
interferon gamma	81(1,1,1,1)	Details
CYP2B	81(1,1,1,1)	Details
CYP2D6	107(0,3,5,7)	Details
G proteins	68(0,2,2,8)	Details
superoxide dismutase	64(0,1,5,14)	Details
CYP1A2	58(0,1,2,23)	Details
aryl hydrocarbon receptor	51(0,1,2,16)	Details
arginine vasopressin	45(0,1,3,5)	Details
neurotrophic factors	44(0,1,2,9)	Details
cytochrome P450 monooxygenases	44(0,1,2,9)	Details
c fos	43(0,1,2,8)	Details
ScFv	42(0,1,2,7)	Details
interleukin 6	41(0,1,2,6)	Details
ATPase	41(0,1,2,6)	Details
glutathione reductase	39(0,1,2,4)	Details
GT1	38(0,1,2,3)	Details
Pf1	35(0,1,1,5)	Details
cholesterol esterase	34(0,1,1,4)	Details
CYP2C8	34(0,1,1,4)	Details
CARB	34(0,1,1,4)	Details
CYP2C9	33(0,1,1,3)	Details
brain 2	33(0,1,1,3)	Details
gamma glutamyl transferase	33(0,1,1,3)	Details
tryptophan hydroxylase	33(0,1,1,3)	Details
caspase (protein family or complex)	33(0,1,1,3)	Details
IL 4	32(0,1,1,2)	Details
glycogen phosphorylase	32(0,1,1,2)	Details
PSCP	32(0,1,1,2)	Details
glucose 6 phosphatase	32(0,1,1,2)	Details
acid phosphatase	31(0,1,1,1)	Details
CACA	31(0,1,1,1)	Details
microtubule associated proteins	31(0,1,1,1)	Details
C10	31(0,1,1,1)	Details
annexin V	25(0,0,4,5)	Details
NR2A	20(0,0,3,5)	Details
NR2B	20(0,0,3,5)	Details
tumor necrosis factor	20(0,0,3,5)	Details
HC5	19(0,0,2,9)	Details
PN 1	19(0,0,1,14)	Details
lactate dehydrogenase (protein family or complex)	18(0,0,2,8)	Details
CA1	17(0,0,2,7)	Details
N methyl D aspartate receptor (protein family or complex)	16(0,0,2,6)	Details
brains	15(0,0,1,10)	Details
CYP2C19	13(0,0,1,8)	Details
hemoglobin (protein family or complex)	12(0,0,0,12)	Details
Hsp89	10(0,0,1,5)	Details
reelin	10(0,0,1,5)	Details
SPMD	10(0,0,1,5)	Details
PN5	9(0,0,1,4)	Details
aspartate aminotransferase	9(0,0,1,4)	Details
TESS	9(0,0,1,4)	Details
alanine aminotransferase	8(0,0,1,3)	Details
transferase	8(0,0,1,3)	Details
pg m	8(0,0,1,3)	Details
choline transporter	8(0,0,0,8)	Details
Golf	8(0,0,1,3)	Details
estrogen receptor	8(0,0,0,8)	Details
IL 1beta	8(0,0,1,3)	Details
protein as	8(0,0,1,3)	Details
metallothionein (protein family or complex)	8(0,0,1,3)	Details
interferon (protein family or complex)	8(0,0,1,3)	Details
transferrin	7(0,0,1,2)	Details
per 1	7(0,0,1,2)	Details
CA3	7(0,0,0,7)	Details
aryl hydrocarbon hydroxylase	7(0,0,1,2)	Details
ps 2	7(0,0,1,2)	Details
CYP1B1	7(0,0,1,2)	Details
cytochrome c	7(0,0,1,2)	Details
Hsp70	7(0,0,1,2)	Details
Protein S	6(0,0,1,1)	Details
K60	6(0,0,1,1)	Details
keratin 10	6(0,0,1,1)	Details
Sp1 transcription factors	6(0,0,1,1)	Details
keratin 1	6(0,0,1,1)	Details
PN3	6(0,0,1,1)	Details
TEPP	6(0,0,1,1)	Details
bcl 2	6(0,0,1,1)	Details
factor is	6(0,0,1,1)	Details
monoamine oxidase A	6(0,0,1,1)	Details
CYP2A6	6(0,0,1,1)	Details
CD8	6(0,0,1,1)	Details
B12	5(0,0,0,5)	Details
pancreatic lipase	4(0,0,0,4)	Details
demethylase	4(0,0,0,4)	Details
tyrosine hydroxylase	4(0,0,0,4)	Details
E cadherin	4(0,0,0,4)	Details
DTNA	4(0,0,0,4)	Details
M2 muscarinic acetylcholine receptor	4(0,0,0,4)	Details
LR3	4(0,0,0,4)	Details
Salvador	4(0,0,0,4)	Details
muscles	3(0,0,0,3)	Details
chitinase	3(0,0,0,3)	Details
mitogen activated protein kinase (protein family or complex)	3(0,0,0,3)	Details
dopamine transporter	3(0,0,0,3)	Details
DTNB	3(0,0,0,3)	Details
protein kinase A (protein family or complex)	3(0,0,0,3)	Details
vesicular acetylcholine transporter	3(0,0,0,3)	Details
CYP19	3(0,0,0,3)	Details
ERbeta	3(0,0,0,3)	Details
PI4 kinase	3(0,0,0,3)	Details
phosphodiesterase	2(0,0,0,2)	Details
complex is	2(0,0,0,2)	Details
xanthine oxidase	2(0,0,0,2)	Details
acylpeptide hydrolase	2(0,0,0,2)	Details
Tyrosinase	2(0,0,0,2)	Details
immunoglobulin (protein family or complex)	2(0,0,0,2)	Details
beta glucuronidase	2(0,0,0,2)	Details
Beach	2(0,0,0,2)	Details
kallikrein	2(0,0,0,2)	Details
CYP3A5	2(0,0,0,2)	Details
protein is	2(0,0,0,2)	Details
cytochrome b5	2(0,0,0,2)	Details
thrombin	2(0,0,0,2)	Details
Koc	2(0,0,0,2)	Details
androgen receptor	2(0,0,0,2)	Details
ZO 1	2(0,0,0,2)	Details
constitutive androstane receptor	2(0,0,0,2)	Details
Asp 1	2(0,0,0,2)	Details
sex hormone binding globulin	2(0,0,0,2)	Details
GPCR	2(0,0,0,2)	Details
NF68	2(0,0,0,2)	Details
Ten 3	2(0,0,0,2)	Details
CD26	2(0,0,0,2)	Details
SLAM	2(0,0,0,2)	Details
arylformamidase	1(0,0,0,1)	Details
glucagon receptors	1(0,0,0,1)	Details
D53	1(0,0,0,1)	Details
got 2	1(0,0,0,1)	Details
Est 2	1(0,0,0,1)	Details
G protein alpha (protein family or complex)	1(0,0,0,1)	Details
stimulatory G proteins	1(0,0,0,1)	Details
cysteine S conjugate beta lyase	1(0,0,0,1)	Details
top 3	1(0,0,0,1)	Details
CERP	1(0,0,0,1)	Details
platelet activating factor acetylhydrolase	1(0,0,0,1)	Details
CYP2	1(0,0,0,1)	Details
IL 5	1(0,0,0,1)	Details
calcium channel (protein family or complex)	1(0,0,0,1)	Details
glucose 6 phosphate dehydrogenase	1(0,0,0,1)	Details
CS2	1(0,0,0,1)	Details
myelin basic protein	1(0,0,0,1)	Details
follicle stimulating hormone (protein family or complex)	1(0,0,0,1)	Details
interleukin 2	1(0,0,0,1)	Details
glutamine synthetase	1(0,0,0,1)	Details
ASAT	1(0,0,0,1)	Details
CD4	1(0,0,0,1)	Details
CAPE	1(0,0,0,1)	Details
P13	1(0,0,0,1)	Details
glucagon	1(0,0,0,1)	Details
succinate dehydrogenase (protein family or complex)	1(0,0,0,1)	Details
Cl 2	1(0,0,0,1)	Details
ubiquitin	1(0,0,0,1)	Details
c jun	1(0,0,0,1)	Details
CD1	1(0,0,0,1)	Details
heme oxygenase 1	1(0,0,0,1)	Details
c Myc	1(0,0,0,1)	Details
methemoglobin	1(0,0,0,1)	Details
monoamine transporter	1(0,0,0,1)	Details
March 1	1(0,0,0,1)	Details
chemokines	1(0,0,0,1)	Details
beta 2 adrenoceptor	1(0,0,0,1)	Details
Aldehyde dehydrogenases (protein family or complex)	1(0,0,0,1)	Details
Avian	1(0,0,0,1)	Details
epidermal growth factor	1(0,0,0,1)	Details
lipoprotein lipase	1(0,0,0,1)	Details
phosphatidylinositol 3 kinase (protein family or complex)	1(0,0,0,1)	Details
HGPRT	1(0,0,0,1)	Details
hormone sensitive lipase	1(0,0,0,1)	Details
TASK 1	1(0,0,0,1)	Details
signal peptidase (protein family or complex)	1(0,0,0,1)	Details
SN2	1(0,0,0,1)	Details
CD5	1(0,0,0,1)	Details
PNGase	1(0,0,0,1)	Details
G protein coupled receptor	1(0,0,0,1)	Details
cytochrome P450scc	1(0,0,0,1)	Details
IL 13	1(0,0,0,1)	Details
deepest	1(0,0,0,1)	Details
glutathione S transferase P	1(0,0,0,1)	Details
HP 1	1(0,0,0,1)	Details
norepinephrine transporters	1(0,0,0,1)	Details
cyclophilin	1(0,0,0,1)	Details
alpha adrenergic receptors (protein family or complex)	1(0,0,0,1)	Details
ES1	1(0,0,0,1)	Details
carboxylesterase 2	1(0,0,0,1)	Details
PI 4 kinase	1(0,0,0,1)	Details
myelin associated glycoprotein	1(0,0,0,1)	Details
nerve growth factor receptors	1(0,0,0,1)	Details
PFM1	1(0,0,0,1)	Details
RLFP	1(0,0,0,1)	Details
gracile	1(0,0,0,1)	Details
mass 1	1(0,0,0,1)	Details
ANBC	1(0,0,0,1)	Details
at V1	1(0,0,0,1)	Details
esterase A4	1(0,0,0,1)	Details
CYP2U1	1(0,0,0,1)	Details
glutamate cysteine ligase (protein family or complex)	1(0,0,0,1)	Details
S100 beta	1(0,0,0,1)	Details
microtubule associated protein 2	1(0,0,0,1)	Details
PKCgamma	1(0,0,0,1)	Details
PFM5	1(0,0,0,1)	Details
CYP2E1	0(0,0,0,0)	Details
p38beta	0(0,0,0,0)	Details
NF H	0(0,0,0,0)	Details
ornithine decarboxylase	0(0,0,0,0)	Details
p38alpha	0(0,0,0,0)	Details
pregnane X receptor	0(0,0,0,0)	Details
MAGE (protein family or complex)	0(0,0,0,0)	Details
HSC70	0(0,0,0,0)	Details
neuron specific enolase	0(0,0,0,0)	Details
PKCalpha	0(0,0,0,0)	Details
ATPase is	0(0,0,0,0)	Details
X receptors	0(0,0,0,0)	Details
not 7	0(0,0,0,0)	Details
MAP1B	0(0,0,0,0)	Details
glutamate receptor	0(0,0,0,0)	Details

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