| Name | ChAT |
|---|---|
| Synonyms | CHAT; CHOACTase; CLAT; CMS1A; CMS1A2; ChAT; Choline O acetyltransferase; Choline acetylase… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16510359 | Pung T, Klein B, Blodgett D, Jortner B, Ehrich M: Examination of concurrent exposure to repeated stress and chlorpyrifos on cholinergic, glutamatergic, and monoamine neurotransmitter systems in rat forebrain regions. Int J Toxicol. 2006 Jan-Feb;25(1):65-80. Effects of concurrent exposure to repeated stress and chlorpyrifos on activities of acetylcholinesterase (AChE), carboxylesterase, and choline acetyltransferase (ChAT); concentrations of excitatory amino acids, monoamines, and their metabolites; and maximum binding densities (B (max)) and equilibrium dissociation rate constants (K (d)) of glutamatergic and total muscarinic cholinergic receptors were studied in the blood, hippocampus, cerebral cortex, or hypothalamus of adult Long-Evans rats. |
31(0,1,1,1) | Details |
| 18941570 | Slotkin TA, Bodwell BE, Ryde IT, Levin ED, Seidler FJ: Exposure of neonatal rats to parathion elicits sex-selective impairment of systems in brain regions during adolescence and adulthood. Environ Health Perspect. 2008 Oct;116(10):1308-14. Epub 2008 May 19. METHODS: We assessed neurochemical indices related to the function of synapses (choline acetyltransferase, presynaptic high-affinity choline transporter, nicotinic cholinergic receptors) in brain regions comprising all the major projections, with determinations carried out from adolescence to adulthood (PNDs 30, 60, and 100). Superimposed on this general pattern, the cerebrocortical effects showed a nonmonotonic dose-response relationship, with regression of the defects at the higher parathion dose; this relationship has been seen also after comparable treatments with chlorpyrifos and diazinon and likely represents the involvement of cholinesterase-related actions that mask or offset the effects of lower doses. |
1(0,0,0,1) | Details |
| 12521672 | Richardson J, Chambers J: Effects of gestational exposure to chlorpyrifos on postnatal central and peripheral cholinergic neurochemistry. J Toxicol Environ Health A. 2003 Feb 14;66(3):275-89. These results indicate that gestational exposure to chlorpyrifos results in relatively persistent inhibition of brain cholinesterase and a delayed depression of choline acetyltransferase at a time when brain cholinesterase activity had returned to control levels in the high-dosage group. |
83(1,1,1,3) | Details |
| 11384617 | Slotkin TA, Cousins MM, Tate CA, Seidler FJ: Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Res. 2001 Jun 1;902(2):229-43. We then examined two cholinergic synaptic markers, choline acetyltransferase activity (ChAT) and [3H] hemicholinium-3 binding (HC-3) in the hippocampus, midbrain, striatum, brainstem and cerebral cortex in the juvenile (PN30) and young adult (PN60). |
3(0,0,0,3) | Details |
| 16675418 | Jameson RR, Seidler FJ, Qiao D, Slotkin TA: Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells. Environ Health Perspect. 2006 May;114(5):667-72. At the same time, CPF increased the expression of tyrosine hydroxylase (TH), the enzymatic marker for the catecholamine phenotype, without affecting choline acetyltransferase (ChAT), the corresponding marker for the cholinergic phenotype. |
3(0,0,0,3) | Details |
| 14600274 | Richardson JR, Chambers JE: Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing rats. Toxicol Sci. 2004 Jan;77(1):83-90. Epub 2003 Nov 4. Pups were euthanized on postnatal days (PND) 1, 3, 6, 9, 12, and 30 for the determination of brain cholinesterase (ChE) and choline acetyltransferase (ChAT) activities, along with muscarinic receptor (mAChR) densities, the levels of the high-affinity uptake (HACU) system, and the vesicular acetylcholine transporter (VAChT). |
2(0,0,0,2) | Details |
| 10446342 | Dam K, Garcia SJ, Seidler FJ, Slotkin TA: Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways. Brain Res Dev Brain Res. 1999 Aug 5;116(1):9-20. Effects on the development of cholinergic neuronal function were assessed using choline acetyltransferase (ChAT) activity and hemicholinium-3 (HC-3) binding as indices of synaptic proliferation and synaptic activity, respectively. |
2(0,0,0,2) | Details |
| 14718179 | Ehrich M, Hancock S, Ward D, Holladay S, Pung T, Flory L, Hinckley J, Jortner BS: Neurologic and immunologic effects of exposure to chlorpyrifos, and multiple doses of tri-ortho-tolyl over a 28-day period in rats. J Toxicol Environ Health A. 2004 Mar 12;67(5):431-57. In addition, choline acetyltransferase, glial acidic fibrillary protein (GFAP), peroxidase, and superoxide dismutase were evaluated in one or more of the brain regions already identified. |
2(0,0,0,2) | Details |
| 19539729 | Slotkin TA, Seidler FJ: Benzo [a] pyrene impairs neurodifferentiation in PC12 cells. Brain Res Bull. 2009 Aug 28;80(1-2):17-21. Epub 2009 Jun 17. In order to determine if BaP directly affects neurodevelopment, we compared its effects to those of the organophosphate insecticide, chlorpyrifos (CPF), in undifferentiated and differentiating neuronotypic PC12 cells, evaluating indices of cell replication, cell number, neurite outgrowth and phenotypic differentiation. We directly confirmed BaP impairment of neurodifferentiation by measuring markers for the two neurotransmitter phenotypes expressed by PC12 cells: tyrosine hydroxylase phenotype) and choline acetyltransferase phenotype). |
1(0,0,0,1) | Details |
| 10873710 | Monnet-Tschudi F, Zurich MG, Schilter B, Costa LG, Honegger P: Maturation-dependent effects of chlorpyrifos and parathion and their analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures. Toxicol Appl Pharmacol. 2000 Jun 15;165(3):175-83. Toxic effects, assessed by measuring protein content as an index of general cytotoxicity, and various enzyme activities as cell-type-specific neuronal and glial markers (ChAT and GAD, for cholinergic and GABAergic neurons, respectively, and GS and CNP, for astrocytes and oligodendrocytes, respectively) were only found at more than 70% of AChE inhibition. |
1(0,0,0,1) | Details |
| 18393628 | Hoogduijn MJ, Cheng A, Genever PG: Functional Nicotinic and Muscarinic Receptors on Mesenchymal Stem Cells. . Stem Cells Dev. 2008 Mar 10. We detected expression of choline acetyltransferase, acetylcholinesterase and the presence of in MSCs. The acetylcholinesterase inhibitor chlorpyrifos, which is widely used as an agricultural insecticide, had similar effects on intracellular Ca2+ and cAMP in MSCs. |
1(0,0,0,1) | Details |
| 15647600 | Richardson JR, Chambers JE: Effects of repeated oral postnatal exposure to chlorpyrifos on cholinergic neurochemistry in developing rats. Toxicol Sci. 2005 Apr;84(2):352-9. Epub 2005 Jan 12. On PND 30 choline acetyltransferase activity and vesicular acetylcholine transporter levels were decreased by 12 and 22%, respectively, only in the high dosage group. |
1(0,0,0,1) | Details |
| 12676612 | Qiao D, Seidler FJ, Tate CA, Cousins MM, Slotkin TA: Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. Environ Health Perspect. 2003 Apr;111(4):536-44. Choline acetyltransferase, a constitutive marker for cholinergic nerve terminals, showed only minor CPF-induced changes during the period of rapid synaptogenesis. |
1(0,0,0,1) | Details |
| 18335101 | Slotkin TA, Bodwell BE, Levin ED, Seidler FJ: Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and systems. Environ Health Perspect. 2008 Mar;116(3):340-8. The patterns seen here differ substantially from those seen in earlier work with chlorpyrifos, reinforcing the concept that the various organophosphates have fundamentally different effects on the developmental trajectories of specific neurotransmitter systems, unrelated to their shared action as cholinesterase inhibitors. METHODS: We then evaluated the lasting effects on indices of neural cell number and size, and on functional markers of synapses (choline acetyltransferase, presynaptic high-affinity choline transporter, nicotinic cholinergic receptors) in a variety of brain regions. |
1(0,0,0,1) | Details |
| 18436430 | Slotkin TA, Seidler FJ, Ryde IT, Yanai J: Developmental effects of chlorpyrifos on and pathways in an avian model. Neurotoxicol Teratol. 2008 Sep-Oct;30(5):433-9. Epub 2008 Mar 18. Choline acetyltransferase, a constitutive marker for terminals, was unaffected. |
1(0,0,0,1) | Details |
| 14757517 | Qiao D, Seidler FJ, Abreu-Villaca Y, Tate CA, Cousins MM, Slotkin TA: Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. Brain Res Dev Brain Res. 2004 Jan 31;148(1):43-52. Choline acetyltransferase (ChAT), a constitutive marker for cholinergic nerve terminals, was increased in the hippocampus and striatum in adolescence and adulthood. |
1(0,0,0,1) | Details |
| 16675431 | Slotkin TA, Levin ED, Seidler FJ: Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ Health Perspect. 2006 May;114(5):746-51. We contrasted neuritic outgrowth and cholinergic synaptic development in neonatal rats given different organophosphates (chlorpyrifos, diazinon, parathion) at doses spanning the threshold for impaired growth and viability. |
0(0,0,0,0) | Details |