| Name | PN 1 |
|---|---|
| Synonyms | GDN; PI7; PN1; Glia derived nexin; Glia derived nexin precursor; Glial derived neurite promoting factor; Glial derived nexin 1; PN 1… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18773955 | Slotkin TA, Levin ED, Seidler FJ: Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood. Neurotoxicol Teratol. 2009 Jan-Feb;31(1):11-7. Epub 2008 Aug 20. We administered parathion to newborn rats on postnatal days (PN) 1-4 at doses spanning the threshold for detectable cholinesterase inhibition (0.1 mg/kg/day) and the first signs of loss of viability (0.2 mg/kg/day). These findings stand in strong contrast to previous results with neonatal exposure to a different organophosphate, chlorpyrifos, which evoked parallel upregulation of all three 5HT synaptic proteins that persisted from adolescence through full adulthood and that targeted males much more than females. |
1(0,0,0,1) | Details |
| 15464859 | Slotkin TA, Southard MC, Adam SJ, Cousins MM, Seidler FJ: Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: and chlorpyrifos. Brain Res Bull. 2004 Sep 30;64(3):227-35. |
0(0,0,0,0) | Details |
| 11675126 | Navarro HA, Basta PV, Seidler FJ, Slotkin TA: Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect?. Brain Res Dev Brain Res. 2001 Oct 24;130(2):249-52. |
0(0,0,0,0) | Details |
| 12611658 | Garcia SJ, Seidler FJ, Slotkin TA: Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities. Environ Health Perspect. 2003 Mar;111(3):297-303. |
0(0,0,0,0) | Details |
| 10876030 | Dam K, Seidler FJ, Slotkin TA: Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. Brain Res Dev Brain Res. 2000 Jun 30;121(2):179-87. |
0(0,0,0,0) | Details |
| 10446342 | Dam K, Garcia SJ, Seidler FJ, Slotkin TA: Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways. Brain Res Dev Brain Res. 1999 Aug 5;116(1):9-20. |
0(0,0,0,0) | Details |
| 10837889 | Auman JT, Seidler FJ, Slotkin TA: Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity. Brain Res Dev Brain Res. 2000 May 11;121(1):19-27. Newborn rats were given 1 mg/kg of chlorpyrifos s.c. on PN1-4. |
6(0,0,1,1) | Details |
| 14754568 | Aldridge JE, Seidler FJ, Slotkin TA: Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ Health Perspect. 2004 Feb;112(2):148-55. In the present study, we evaluated the effects in adulthood after CPF exposures from the neural tube stage [gestational days (GD) 9-12] and the late gestational period (GD17-20) through postnatal neuronal differentiation and synaptogenesis [postnatal days (PN) 1-4 and 11-14], using treatments below the threshold for systemic toxicity. |
2(0,0,0,2) | Details |
| 14754571 | Meyer A, Seidler FJ, Slotkin TA: Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. Environ Health Perspect. 2004 Feb;112(2):170-8. In the present study, we evaluated the immediate and long-term effects of CPF exposure of rats during different developmental windows [gestational days (GD) 9-12 or 17-20, postnatal days (PN) 1-4 or 11-14] on the adenylyl cyclase (AC) signaling cascade in the heart and liver. |
2(0,0,0,2) | Details |
| 11384617 | Slotkin TA, Cousins MM, Tate CA, Seidler FJ: Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Res. 2001 Jun 1;902(2):229-43. In the midbrain, CPF administration on PN1-4 elicited deficits similar to those seen in the hippocampus; however, exposure on PN11-14 elicited changes preferentially in females. |
2(0,0,0,2) | Details |
| 14594624 | Aldridge JE, Seidler FJ, Meyer A, Thillai I, Slotkin TA: Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. Environ Health Perspect. 2003 Nov;111(14):1736-43. We evaluated four different treatment windows ranging from the neural tube stage [gestational days (GD) 9-12] and the late gestational period (GD17-20) through postnatal phases of terminal neuronal differentiation and synaptogenesis [postnatal days (PN) 1-4, PN11-14]. |
1(0,0,0,1) | Details |
| 14998743 | Meyer A, Seidler FJ, Aldridge JE, Tate CA, Cousins MM, Slotkin TA: Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. Environ Health Perspect. 2004 Mar;112(3):295-301. Animals were exposed on gestational days (GD) 9-12 or 17-20 or on postnatal days (PN) 1-4 or 11-14 and assessed at PN60. |
1(0,0,0,1) | Details |
| 11882346 | Slotkin TA, Tate CA, Cousins MM, Seidler FJ: Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure. Brain Res Dev Brain Res. 2002 Feb 28;133(2):163-73. We administered CPF to neonatal rats on postnatal days (PN) 1-4 (1 mg/kg) or PN11-14 (5 mg/kg), regimens devoid of overt systemic toxicity. |
1(0,0,0,1) | Details |
| 16079074 | Aldridge JE, Meyer A, Seidler FJ, Slotkin TA: Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. Environ Health Perspect. 2005 Aug;113(8):1027-31. To characterize the synaptic mechanisms underlying these effects, we exposed developing rats to CPF regimens below the threshold for systemic toxicity, in three treatment windows: gestational days (GD) 17-20, postnatal days (PN) 1-4, or PN11-14. |
1(0,0,0,1) | Details |
| 11557094 | Raines KW, Seidler FJ, Slotkin TA: Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. Brain Res Dev Brain Res. 2001 Sep 23;130(1):65-72. We administered CPF to neonatal rats on postnatal days (PN) 1-4 (1 mg/kg) or PN11-14 (5 mg/kg), treatments devoid of overt toxicity. |
1(0,0,0,1) | Details |
| 11882345 | Garcia SJ, Seidler FJ, Qiao D, Slotkin TA: Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein. Brain Res Dev Brain Res. 2002 Feb 28;133(2):151-61. Early postnatal (PN) CPF treatment (PN1-4) elicited effects only in the cerebellum of male rats; GFAP was suppressed initially (PN5) and showed a rebound elevation (PN10) before returning to normal values by PN30. |
1(0,0,0,1) | Details |