| Name | acetylcholine receptor (protein family or complex) |
|---|---|
| Synonyms | Acetylcholine receptor; Acetylcholine receptors |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17666426 | Guo-Ross SX, Chambers JE, Meek EC, Carr RL: Altered muscarinic acetylcholine receptor subtype binding in neonatal rat brain following exposure to chlorpyrifos or methyl parathion. Toxicol Sci. 2007 Nov;100(1):118-27. Epub 2007 Jul 31. |
112(1,2,2,2) | Details |
| 15464859 | Slotkin TA, Southard MC, Adam SJ, Cousins MM, Seidler FJ: Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: and chlorpyrifos. Brain Res Bull. 2004 Sep 30;64(3):227-35. |
82(1,1,1,2) | Details |
| 9344890 | Katz EJ, Cortes VI, Eldefrawi ME, Eldefrawi AT: Chlorpyrifos, parathion, and their oxons bind to and desensitize a nicotinic acetylcholine receptor: relevance to their toxicities. Toxicol Appl Pharmacol. 1997 Oct;146(2):227-36. |
82(1,1,1,2) | Details |
| 12937891 | Abou-Donia MB, Abdel-Rahman A, Goldstein LB, Dechkovskaia AM, Shah DU, Bullman SL, Khan WA: Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or in rats. Arch Toxicol. 2003 Aug;77(8):452-8. Epub 2003 Apr 26. A significant increase in ligand binding to nicotinic acetylcholine receptors (nAChR) was observed in brainstem and cortex following exposure to or chlorpyrifos. |
37(0,1,2,2) | Details |
| 16510359 | Pung T, Klein B, Blodgett D, Jortner B, Ehrich M: Examination of concurrent exposure to repeated stress and chlorpyrifos on cholinergic, glutamatergic, and monoamine neurotransmitter systems in rat forebrain regions. Int J Toxicol. 2006 Jan-Feb;25(1):65-80. However, the interactions between stress and chlorpyrifos significant at p < 0.05 were restricted to attenuation of elevated in the hippocampus of restrained with swim rats and decreased K (d) of acetylcholine receptors in the cerebral cortex of swum rats and restrained rats. |
31(0,1,1,1) | Details |
| 14600285 | Betancourt AM, Carr RL: The effect of chlorpyrifos and chlorpyrifos-oxon on brain cholinesterase, muscarinic receptor binding, and neurotrophin levels in rats following early postnatal exposure. Toxicol Sci. 2004 Jan;77(1):63-71. Epub 2003 Nov 4. The effects of repeated postnatal exposure to CPS and its metabolite chlorpyrifos-oxon (CPO) on total muscarinic acetylcholine receptor (mAChR) binding, nerve growth factor (NGF) levels, and brain derived neurotrophic factor (BDNF) levels in the forebrain of neonatal rats were investigated. |
31(0,1,1,1) | Details |
| 18977431 | Eells JB, Brown T: Repeated developmental exposure to chlorpyrifos and methyl parathion causes persistent alterations in nicotinic subunit mRNA expression with chlorpyrifos altering metabolite levels. Neurotoxicol Teratol. 2009 Mar-Apr;31(2):98-103. Epub 2008 Oct 21. Nigrostriatal dopamine neurons receive substantial cholinergic innervation and express a number of nicotinic acetylcholine receptor subunits. |
2(0,0,0,2) | Details |
| 19268529 | Eddins D, Cerutti D, Williams P, Linney E, Levin ED: Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with and pilocarpine effects and relationship to deficits. Neurotoxicol Teratol. 2010 Jan-Feb;32(1):99-108. Epub 2009 Mar 4. To elucidate the contributions of nicotinic and muscarinic acetylcholine receptors to developmental CPF-mediated effects, the effects of developmental and pilocarpine exposure throughout the first five days after fertilization were determined. |
1(0,0,0,1) | Details |
| 11876500 | Zhang H, Liu J, Pope CN: Age-related effects of chlorpyrifos on muscarinic receptor-mediated signaling in rat cortex. Arch Toxicol. 2002 Jan;75(11-12):676-84. A number of studies suggest that in addition to inhibiting acetylcholinesterase (AChE), CPF oxon may also interact directly with m2 and/or m4 subtypes of muscarinic acetylcholine receptors (mAChRs). |
1(0,0,0,1) | Details |
| 14741763 | Qiao D, Seidler FJ, Violin JD, Slotkin TA: is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. Brain Res Dev Brain Res. 2003 Dec 30;147(1-2):183-90. The effects were blocked by mecamylamine, indicating mediation by nicotinic acetylcholine receptors. |
1(0,0,0,1) | Details |
| 18393628 | Hoogduijn MJ, Cheng A, Genever PG: Functional Nicotinic and Muscarinic Receptors on Mesenchymal Stem Cells. . Stem Cells Dev. 2008 Mar 10. MSCs also expressed the nicotinic acetylcholine receptor subunits a3, a5, a7 and the muscarinic acetylcholine receptor 2 (M2-receptor). The acetylcholinesterase inhibitor chlorpyrifos, which is widely used as an agricultural insecticide, had similar effects on intracellular Ca2+ and cAMP in MSCs. |
1(0,0,0,1) | Details |
| 17548533 | Terry AV Jr, Gearhart DA, Beck WD Jr, Truan JN, Middlemore ML, Williamson LN, Bartlett MG, Prendergast MA, Sickles DW, Buccafusco JJ: Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing. J Pharmacol Exp Ther. 2007 Sep;322(3):1117-28. Epub 2007 Jun 4. Furthermore, the 18.0 mg/kg dose of CPF was associated with (brain region-dependent) decreases in nerve growth factor receptors and cholinergic proteins including the vesicular acetylcholine transporter, the high-affinity choline transporter, and the alpha (7)-nicotinic acetylcholine receptor. |
1(0,0,0,1) | Details |
| 11822358 | Buznikov GA, Bezuglov VV, Nikitina LA, Slotkin TA, Lauder JM: [Cholinergic regulation of the sea urchin embryonic and larval development]. Ross Fiziol Zh Im I M Sechenova. 2001 Nov;87(11):1548-56. The organophosphate pesticide, chlorpyrifos, or a combination of (-)- + phorbol 12- 13- also evoke the mass extrusion of transformed embryonic cells at the animal pole of larvae. Taking together, these results suggest that AA-Ch and DHA-Ch act on sea urchin embryos and larvae as agonists of acetylcholine receptors, whereas AA-DMAE and DHA-DMAE act as antagonists. |
1(0,0,0,1) | Details |
| 15647600 | Richardson JR, Chambers JE: Effects of repeated oral postnatal exposure to chlorpyrifos on cholinergic neurochemistry in developing rats. Toxicol Sci. 2005 Apr;84(2):352-9. Epub 2005 Jan 12. Total muscarinic acetylcholine receptors (mAChR) were reduced in a dose-related manner on PND 12 and 22, with substantial recovery by PND 30. |
1(0,0,0,1) | Details |
| 15342957 | Smulders CJ, Bueters TJ, Vailati S, van Kleef RG, Vijverberg HP: Block of neuronal nicotinic acetylcholine receptors by organophosphate insecticides. Toxicol Sci. 2004 Dec;82(2):545-54. Epub 2004 Sep 1. Several OP pesticides, e.g., parathion-ethyl, chlorpyrifos and disulfoton, inhibited the -induced ion current with potencies in the micromolar range. |
1(0,0,0,1) | Details |
| 16675515 | Betancourt AM, Burgess SC, Carr RL: Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain. Toxicol Sci. 2006 Aug;92(2):500-6. Epub 2006 May 4. In addition, the expression of mRNA for the muscarinic acetylcholine receptor (mAChR) M (1) subtype and cell-specific markers for developing neurons (beta-III tubulin), astrocytes (glial fibrillary acidic protein, GFAP), and oligodendrocytes (myelin-associated glycoprotein, MAG) was also investigated. |
1(0,0,0,1) | Details |
| 14514956 | Tang J, Carr RL, Chambers JE: The effects of repeated oral exposures to methyl parathion on rat brain cholinesterase and muscarinic receptors during postnatal development. Toxicol Sci. 2003 Dec;76(2):400-6. Epub 2003 Sep 26. This may result in differences in toxic signs and tolerance development after treatment of juvenile rats with methyl parathion (MPS), a dimethyl phosphorothionate, than after treatment with chlorpyrifos (CPS), a diethyl phosphorothionate. The effects of repeated MPS exposures on brain ChE activity and surface and total muscarinic acetylcholine receptor (mAChR) density were studied in postnatal rats gavaged daily from postnatal day 1 (PND1) through PND 21. |
1(0,0,0,1) | Details |
| 14998686 | Rhodes MC, Seidler FJ, Qiao D, Tate CA, Cousins MM, Slotkin TA: Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. Toxicol Appl Pharmacol. 2004 Mar 1;195(2):203-17. Indices of cholinergic synaptic activity [hemicholinium-3 and -muscarinic acetylcholine receptor binding] showed impairment after exposure to either terbutaline or CPF but the effects were more severe when the treatments were combined. |
1(0,0,0,1) | Details |
| 11083088 | Bomser J, Casida JE: Activation of extracellular signal-regulated kinases (ERK 44/42) by chlorpyrifos oxon in Chinese hamster ovary cells. J Biochem Mol Toxicol. 2000;14(6):346-53. |
0(0,0,0,0) | Details |
| 15045467 | Abdel-Rahman A, Dechkovskaia AM, Mehta-Simmons H, Sutton JM, Guan X, Khan WA, Abou-Donia MB: Maternal exposure to and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty. Arch Toxicol. 2004 Aug;78(8):467-76. Epub 2004 Mar 26. |
0(0,0,0,0) | Details |